Complement genes contribute sex-biased vulnerability in diverse disorders.
Adult
Alleles
Complement C3
/ analysis
Complement C4
/ analysis
Female
Genetic Predisposition to Disease
HLA Antigens
/ genetics
Haplotypes
Humans
Lupus Erythematosus, Systemic
/ blood
Major Histocompatibility Complex
/ genetics
Male
Middle Aged
Sex Characteristics
Sjogren's Syndrome
/ blood
Young Adult
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
10
2019
accepted:
28
02
2020
pubmed:
6
6
2020
medline:
21
10
2020
entrez:
6
6
2020
Statut:
ppublish
Résumé
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren's syndrome affect nine times more women than men
Identifiants
pubmed: 32499649
doi: 10.1038/s41586-020-2277-x
pii: 10.1038/s41586-020-2277-x
pmc: PMC7319891
mid: NIHMS1569851
doi:
Substances chimiques
Complement C3
0
Complement C4
0
HLA Antigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-581Subventions
Organisme : NIMH NIH HHS
ID : R01 MH104964
Pays : United States
Organisme : Medical Research Council
ID : MR/L002604/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801418
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH105653
Pays : United States
Organisme : Medical Research Council
ID : MR/T04604X/1
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : R56 HG006855
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI024717
Pays : United States
Organisme : Medical Research Council
ID : MR/P005748/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH123451
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH112491
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH105641
Pays : United States
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085548
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG006855
Pays : United States
Organisme : Medical Research Council
ID : G0901310
Pays : United Kingdom
Investigateurs
Stephan Ripke
(S)
Benjamin M Neale
(BM)
Aiden Corvin
(A)
James T R Walters
(JTR)
Kai-How Farh
(KH)
Peter A Holmans
(PA)
Phil Lee
(P)
Brendan Bulik-Sullivan
(B)
David A Collier
(DA)
Hailiang Huang
(H)
Tune H Pers
(TH)
Ingrid Agartz
(I)
Esben Agerbo
(E)
Margot Albus
(M)
Madeline Alexander
(M)
Farooq Amin
(F)
Silviu A Bacanu
(SA)
Martin Begemann
(M)
Richard A Belliveau
(RA)
Judit Bene
(J)
Sarah E Bergen
(SE)
Elizabeth Bevilacqua
(E)
Tim B Bigdeli
(TB)
Donald W Black
(DW)
Richard Bruggeman
(R)
Nancy G Buccola
(NG)
Randy L Buckner
(RL)
William Byerley
(W)
Wiepke Cahn
(W)
Guiqing Cai
(G)
Murray J Cairns
(MJ)
Dominique Campion
(D)
Rita M Cantor
(RM)
Vaughan J Carr
(VJ)
Noa Carrera
(N)
Stanley V Catts
(SV)
Kimberly D Chambert
(KD)
Raymond C K Chan
(RCK)
Ronald Y L Chen
(RYL)
Eric Y H Chen
(EYH)
Wei Cheng
(W)
Eric F C Cheung
(EFC)
Siow Ann Chong
(SA)
C Robert Cloninger
(CR)
David Cohen
(D)
Nadine Cohen
(N)
Paul Cormican
(P)
Nick Craddock
(N)
Benedicto Crespo-Facorro
(B)
James J Crowley
(JJ)
David Curtis
(D)
Michael Davidson
(M)
Kenneth L Davis
(KL)
Franziska Degenhardt
(F)
Jurgen Del Favero
(J)
Lynn E DeLisi
(LE)
Ditte Demontis
(D)
Dimitris Dikeos
(D)
Timothy Dinan
(T)
Srdjan Djurovic
(S)
Gary Donohoe
(G)
Elodie Drapeau
(E)
Jubao Duan
(J)
Frank Dudbridge
(F)
Naser Durmishi
(N)
Peter Eichhammer
(P)
Johan Eriksson
(J)
Valentina Escott-Price
(V)
Laurent Essioux
(L)
Ayman H Fanous
(AH)
Martilias S Farrell
(MS)
Josef Frank
(J)
Lude Franke
(L)
Robert Freedman
(R)
Nelson B Freimer
(NB)
Marion Friedl
(M)
Joseph I Friedman
(JI)
Menachem Fromer
(M)
Giulio Genovese
(G)
Lyudmila Georgieva
(L)
Elliot S Gershon
(ES)
Ina Giegling
(I)
Paola Giusti-Rodríguez
(P)
Stephanie Godard
(S)
Jacqueline I Goldstein
(JI)
Vera Golimbet
(V)
Srihari Gopal
(S)
Jacob Gratten
(J)
Lieuwe de Haan
(L)
Marina Mitjans
(M)
Marian L Hamshere
(ML)
Mark Hansen
(M)
Thomas Hansen
(T)
Vahram Haroutunian
(V)
Annette M Hartmann
(AM)
Frans A Henskens
(FA)
Stefan Herms
(S)
Joel N Hirschhorn
(JN)
Per Hoffmann
(P)
Andrea Hofman
(A)
Mads V Hollegaard
(MV)
David M Hougaard
(DM)
Masashi Ikeda
(M)
Inge Joa
(I)
Antonio Julià
(A)
René S Kahn
(RS)
Luba Kalaydjieva
(L)
Sena Karachanak-Yankova
(S)
Juha Karjalainen
(J)
David Kavanagh
(D)
Matthew C Keller
(MC)
Brian J Kelly
(BJ)
James L Kennedy
(JL)
Andrey Khrunin
(A)
Yunjung Kim
(Y)
Janis Klovins
(J)
James A Knowles
(JA)
Bettina Konte
(B)
Vaidutis Kucinskas
(V)
Zita Ausrele Kucinskiene
(ZA)
Hana Kuzelova-Ptackova
(H)
Anna K Kähler
(AK)
Claudine Laurent
(C)
Jimmy Lee Chee Keong
(JLC)
S Hong Lee
(SH)
Sophie E Legge
(SE)
Bernard Lerer
(B)
Miaoxin Li
(M)
Tao Li
(T)
Kung-Yee Liang
(KY)
Jeffrey Lieberman
(J)
Svetlana Limborska
(S)
Carmel M Loughland
(CM)
None Jan Lubinski
Jouko Lönnqvist
(J)
Milan Macek
(M)
Patrik K E Magnusson
(PKE)
Brion S Maher
(BS)
Wolfgang Maier
(W)
Jacques Mallet
(J)
Sara Marsal
(S)
Manuel Mattheisen
(M)
Morten Mattingsdal
(M)
Robert W McCarley
(RW)
Colm McDonald
(C)
Andrew M McIntosh
(AM)
Sandra Meier
(S)
Carin J Meijer
(CJ)
Bela Melegh
(B)
Ingrid Melle
(I)
Raquelle I Mesholam-Gately
(RI)
Andres Metspalu
(A)
Patricia T Michie
(PT)
Lili Milani
(L)
Vihra Milanova
(V)
Younes Mokrab
(Y)
Derek W Morris
(DW)
Ole Mors
(O)
Kieran C Murphy
(KC)
Robin M Murray
(RM)
Inez Myin-Germeys
(I)
Bertram Müller-Myhsok
(B)
Mari Nelis
(M)
Igor Nenadic
(I)
Deborah A Nertney
(DA)
Gerald Nestadt
(G)
Kristin K Nicodemus
(KK)
Liene Nikitina-Zake
(L)
Laura Nisenbaum
(L)
Annelie Nordin
(A)
Eadbhard O'Callaghan
(E)
Colm O'Dushlaine
(C)
F Anthony O'Neill
(FA)
Sang-Yun Oh
(SY)
Ann Olincy
(A)
Line Olsen
(L)
Jim Van Os
(J)
Christos Pantelis
(C)
George N Papadimitriou
(GN)
Agnes A Steixner
(AA)
Elena Parkhomenko
(E)
Michele T Pato
(MT)
Tiina Paunio
(T)
Milica Pejovic-Milovancevic
(M)
Diana O Perkins
(DO)
Olli Pietiläinen
(O)
Jonathan Pimm
(J)
Andrew J Pocklington
(AJ)
John Powell
(J)
Alkes Price
(A)
Ann E Pulver
(AE)
Shaun M Purcell
(SM)
Digby Quested
(D)
Henrik B Rasmussen
(HB)
Abraham Reichenberg
(A)
Mark A Reimers
(MA)
Alexander L Richards
(AL)
Joshua L Roffman
(JL)
Panos Roussos
(P)
Douglas M Ruderfer
(DM)
Veikko Salomaa
(V)
Alan R Sanders
(AR)
Ulrich Schall
(U)
Christian R Schubert
(CR)
Thomas G Schulze
(TG)
Sibylle G Schwab
(SG)
Edward M Scolnick
(EM)
Rodney J Scott
(RJ)
Larry J Seidman
(LJ)
Jianxin Shi
(J)
Engilbert Sigurdsson
(E)
Teimuraz Silagadze
(T)
Jeremy M Silverman
(JM)
Kang Sim
(K)
Petr Slominsky
(P)
Jordan W Smoller
(JW)
Hon-Cheong So
(HC)
Chris C A Spencer
(CCA)
Eli A Stahl
(EA)
Hreinn Stefansson
(H)
Stacy Steinberg
(S)
Elisabeth Stogmann
(E)
Richard E Straub
(RE)
Eric Strengman
(E)
Jana Strohmaier
(J)
T Scott Stroup
(TS)
Mythily Subramaniam
(M)
Jaana Suvisaari
(J)
Dragan M Svrakic
(DM)
Jin P Szatkiewicz
(JP)
Erik Söderman
(E)
Srinivas Thirumalai
(S)
Draga Toncheva
(D)
Paul A Tooney
(PA)
Sarah Tosato
(S)
Juha Veijola
(J)
John Waddington
(J)
Dermot Walsh
(D)
Dai Wang
(D)
Qiang Wang
(Q)
Bradley T Webb
(BT)
Mark Weiser
(M)
Dieter B Wildenauer
(DB)
Nigel M Williams
(NM)
Stephanie Williams
(S)
Stephanie H Witt
(SH)
Aaron R Wolen
(AR)
Emily H M Wong
(EHM)
Brandon K Wormley
(BK)
Jing Qin Wu
(JQ)
Hualin Simon Xi
(HS)
Clement C Zai
(CC)
Xuebin Zheng
(X)
Fritz Zimprich
(F)
Naomi R Wray
(NR)
Kari Stefansson
(K)
Peter M Visscher
(PM)
Rolf Adolfsson
(R)
Ole A Andreassen
(OA)
Douglas H R Blackwood
(DHR)
Elvira Bramon
(E)
Joseph D Buxbaum
(JD)
Anders D Børglum
(AD)
Sven Cichon
(S)
Ariel Darvasi
(A)
Enrico Domenici
(E)
Hannelore Ehrenreich
(H)
Tõnu Esko
(T)
Pablo V Gejman
(PV)
Michael Gill
(M)
Hugh Gurling
(H)
Christina M Hultman
(CM)
Nakao Iwata
(N)
Assen V Jablensky
(AV)
Erik G Jönsson
(EG)
Kenneth S Kendler
(KS)
George Kirov
(G)
Jo Knight
(J)
Todd Lencz
(T)
Douglas F Levinson
(DF)
Qingqin S Li
(QS)
Jianjun Liu
(J)
Anil K Malhotra
(AK)
Steven A McCarroll
(SA)
Andrew McQuillin
(A)
Jennifer L Moran
(JL)
Preben B Mortensen
(PB)
Bryan J Mowry
(BJ)
Markus M Nöthen
(MM)
Roel A Ophoff
(RA)
Michael J Owen
(MJ)
Aarno Palotie
(A)
Carlos N Pato
(CN)
Tracey L Petryshen
(TL)
Danielle Posthuma
(D)
Marcella Rietschel
(M)
Brien P Riley
(BP)
None Dan Rujescu
Pak C Sham
(PC)
Pamela Sklar
(P)
David St Clair
(DS)
Daniel R Weinberger
(DR)
Jens R Wendland
(JR)
Thomas Werge
(T)
Mark J Daly
(MJ)
Patrick F Sullivan
(PF)
Michael C O'Donovan
(MC)
Maria J Arranz
(MJ)
Steven Bakker
(S)
Stephan Bender
(S)
Elvira Bramon
(E)
David A Collier
(DA)
Benedicto Crespo-Facorro
(B)
Jeremy Hall
(J)
Conrad Iyegbe
(C)
Assen V Jablensky
(AV)
René S Kahn
(RS)
Luba Kalaydjieva
(L)
Stephen Lawrie
(S)
Cathryn M Lewis
(CM)
Kuang Lin
(K)
Don H Linszen
(DH)
Ignacio Mata
(I)
Andrew M McIntosh
(AM)
Robin M Murray
(RM)
Roel A Ophoff
(RA)
Jim Van Os
(J)
John Powell
(J)
Dan Rujescu
(D)
Muriel Walshe
(M)
Matthias Weisbrod
(M)
Durk Wiersma
(D)
Peter Donnelly
(P)
Ines Barroso
(I)
Jenefer M Blackwell
(JM)
Elvira Bramon
(E)
Matthew A Brown
(MA)
Juan P Casas
(JP)
Aiden Corvin
(A)
Panos Deloukas
(P)
Audrey Duncanson
(A)
Janusz Jankowski
(J)
Hugh S Markus
(HS)
Christopher G Mathew
(CG)
Colin N A Palmer
(CNA)
Robert Plomin
(R)
Anna Rautanen
(A)
Stephen J Sawcer
(SJ)
Richard C Trembath
(RC)
Ananth C Viswanathan
(AC)
Nicholas W Wood
(NW)
Chris C A Spencer
(CCA)
Gavin Band
(G)
Céline Bellenguez
(C)
Peter Donnelly
(P)
Colin Freeman
(C)
Eleni Giannoulatou
(E)
Garrett Hellenthal
(G)
Richard Pearson
(R)
Matti Pirinen
(M)
Amy Strange
(A)
Zhan Su
(Z)
Damjan Vukcevic
(D)
Cordelia Langford
(C)
Ines Barroso
(I)
Hannah Blackburn
(H)
Suzannah J Bumpstead
(SJ)
Panos Deloukas
(P)
Serge Dronov
(S)
Sarah Edkins
(S)
Matthew Gillman
(M)
Emma Gray
(E)
Rhian Gwilliam
(R)
Naomi Hammond
(N)
Sarah E Hunt
(SE)
Alagurevathi Jayakumar
(A)
Jennifer Liddle
(J)
Owen T McCann
(OT)
Simon C Potter
(SC)
Radhi Ravindrarajah
(R)
Michelle Ricketts
(M)
Avazeh Tashakkori-Ghanbaria
(A)
Matthew Waller
(M)
Paul Weston
(P)
Pamela Whittaker
(P)
Sara Widaa
(S)
Christopher G Mathew
(CG)
Jenefer M Blackwell
(JM)
Matthew A Brown
(MA)
Aiden Corvin
(A)
Mark I McCarthy
(MI)
Chris C A Spencer
(CCA)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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