Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk: Towards a dimensional approach.
D2/3 receptors
PET
alcohol
dependence
dopamine
high risk
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
18
10
2019
revised:
09
04
2020
accepted:
17
04
2020
pubmed:
6
6
2020
medline:
19
1
2022
entrez:
6
6
2020
Statut:
ppublish
Résumé
Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying
Substances chimiques
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12915Informations de copyright
© 2020 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
Références
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC; 2013.
Heinz A, Schmidt LG, Reischies FM. Anhedonia in schizophrenic, depressed, or alcohol-dependent patients-neurobiological correlates. Pharmacopsychiatry. 1994;27(Suppl 1):7-10. https://doi.org/10.1055/s-2007-1014317
Krueger RF, Markon KE. The role of the DSM-5 personality trait model in moving toward a quantitative and empirically based approach to classifying personality and psychopathology. Annu Rev Clin Psychol. 2014;10:477-501. https://doi.org/10.1146/annurev-clinpsy-032813-153732
Waszczuk MA, Zimmerman M, Ruggero C, et al. What do clinicians treat: diagnoses or symptoms? The incremental validity of a symptom-based, dimensional characterization of emotional disorders in predicting medication prescription patterns. Compr Psychiatry. 2017;79:80-88. https://doi.org/10.1016/j.comppsych.2017.04.004
Krueger RF, Kotov R, Watson D, et al. Progress in achieving quantitative classification of psychopathology. World Psychiatry. 2018;17(3):282-293. https://doi.org/10.1002/wps.20566
Tambs K, Czajkowsky N, Røysamb E, et al. Structure of genetic and environmental risk factors for dimensional representations of DSM-IV anxiety disorders. Br J Psychiatry. 2009;195(4):301-307. https://doi.org/10.1192/bjp.bp.108.059485
Becker A, Gerchen MF, Kirsch M, Hoffmann S, Kiefer F, Kirsch P. Striatal reward sensitivity predicts therapy-related neural changes in alcohol addiction. Eur Arch Psychiatry Clin Neurosci. 2018;268(3):231-242. https://doi.org/10.1007/s00406-017-0805-y
Ekhtiari H, Rezapour T, Aupperle RL, Paulus MP. Neuroscience-informed psychoeducation for addiction medicine: a neurocognitive perspective. Prog Brain Res. 2017;235:239-264. https://doi.org/10.1016/bs.pbr.2017.08.013
Heinz A, Deserno L, Zimmermann US, Smolka MN, Beck A, Schlagenhauf F. Targeted intervention: computational approaches to elucidate and predict relapse in alcoholism. Neuroimage. 2017;151:33-44. https://doi.org/10.1016/j.neuroimage.2016.07.055
Sebold M, Nebe S, Garbusow M, et al. When habits are dangerous: alcohol expectancies and habitual decision making predict relapse in alcohol dependence. Biol Psychiatry. 2017;82(11):847-856. https://doi.org/10.1016/j.biopsych.2017.04.019
World Health Organisation. Global status report on alcohol and health. 2014.
Saitz R. Unhealthy alcohol use. New England Journal of Medicine. 2005;352(6):596-607. https://doi.org/10.1056/NEJMcp042262
Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35(1):217-238. https://doi.org/10.1038/npp.2009.110
Kamp F, Proebstl L, Penzel N, Adorjan K, Ilankovic A, Pogarell O, Koller G, Soyka M, Falkai P, Koutsouleris N, Kambeitz J Effects of sedative drug use on the dopamine system: a systematic review and meta-analysis of in vivo neuroimaging studies. Neuropsychopharmacology August 2018. https://doi.org/10.1038/s41386-018-0191-9, 44, 4, 660, 667
Di Chiara G. Alcohol and dopamine. Alcohol Health Res World. 1997;21(2):108-114.
Boileau I, Assaad J-M, Pihl RO, et al. Alcohol promotes dopamine release in the human nucleus accumbens. Synapse. 2003;49(4):226-231. https://doi.org/10.1002/syn.10226
Schultz W, Dayan P, Montague PR. A neural substrate of prediction and reward. Science. 1997;275(5306):1593-1599.
Schuckit MA. Alcohol and Alcoholism. In: Harrison's Principles of Internal Medicine. 18th ed. New York, NY: McGraw-Hill; 2016.
Heinz A, Siessmeier T, Wrase J, et al. Correlation between dopamine D2 receptors in the ventral striatum and central processing of alcohol cues and craving. AJP. 2004;161(10):1783-1789. https://doi.org/10.1176/ajp.161.10.1783
Heinz A, Siessmeier T, Wrase J, et al. Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients. AJP. 2005;162(8):1515-1520. https://doi.org/10.1176/appi.ajp.162.8.1515
Heinz A. Dopaminergic dysfunction in alcoholism and schizophrenia-psychopathological and behavioral correlates. Eur Psychiatry. 2002;17(1):9-16.
Robinson TE, Berridge KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 1993;18(3):247-291.
Hirth N, Meinhardt MW, Noori HR, et al. Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence. Proc Natl Acad Sci U S a. 2016;113(11):3024-3029. https://doi.org/10.1073/pnas.1506012113
Barsaglini A, Sartori G, Benetti S, Pettersson-Yeo W, Mechelli A. The effects of psychotherapy on brain function: a systematic and critical review. Prog Neurobiol. 2014;114:1-14. https://doi.org/10.1016/j.pneurobio.2013.10.006
Kühn S, Charlet K, Schubert F, et al. Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence. JAMA Psychiat. 2014;71(7):806-811. https://doi.org/10.1001/jamapsychiatry.2014.352
Jacobi F, Mack S, Gerschler A, et al. The design and methods of the mental health module in the German Health Interview and Examination Survey for Adults (DEGS1-MH). Int J Methods Psychiatr Res. 2013;22(2):83-99. https://doi.org/10.1002/mpr.1387
Wittchen HU, Pfister H. DIA-X-Interviews: Manual Fur Screening-Verfahren Und Interview; Interviewheft Langsschnittuntersuchung (DIA-X-Lifetime); Erganzungsheft (DIA-X-Lifetime); Interviewheft Querschnittuntersuchung (DIA-X-12 Monate); Erganzungsheft (DIA-X-12Monate); PC-Programm Zur Durchfuhrung Des Interviews (Langsund Querschnittuntersuchung); Auswertungsprogramm. Frankfurt: Swets & Zeitlinger; 1997.
Saunders JB, Aasland OG, Babor TF, De La Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addiction. 1993;88(6):791-804. https://doi.org/10.1111/j.1360-0443.1993.tb02093.x
Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Arch Intern Med. 1998;158(16):1789-1795.
Conigrave KM, Hall WD, Saunders JB. The AUDIT questionnaire: Choosing acut-off score. Alcohol Use Disorder Identification Test. Addiction. 1995;90(10):1349-1356.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. , Text Rev. Washington, DC; 2000.
Surti S, Kuhn, A, Werner ME, Perkins AE, Kolthammer J, Karp JS. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. J Nucl Med. 2007;48(3):471-480.
Mukherjee J, Yang ZY, Das MK, Brown T. Fluorinated benzamide neuroleptics-III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer. Nucl Med Biol. 1995;22(3):283-296.
Slifstein M, Hwang D-R, Huang Y, et al. In vivo affinity of [18F]fallypride for striatal and extrastriataldopamine D2 receptors in nonhuman primates. Psychopharmacology. 2004;175(3):274-286. https://doi.org/10.1007/s00213-004-1830-x
Slifstein M, Kegeles LS, Xu X, et al. Striatal and extrastriataldopamine release measured with PET and [(18)F] fallypride. Synapse. 2010;64(5):350-362. https://doi.org/10.1002/syn.20734
Wu Y, Carson RE. Noise reduction in the simplified reference tissue model for Neuroreceptor Functional Imaging. J Cereb Blood Flow Metab. 2002;22(12):1440-1452. https://doi.org/10.1097/01.WCB.0000033967.83623.34
Innis RB, Cunningham VJ, Delforge J, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. Journal of Cerebral Blood Flow & Metabolism. 2007;27(9):1533-1539. https://doi.org/10.1038/sj.jcbfm.9600493
Ishibashi K, Robertson CL, Mandelkern MA, Morgan AT, London ED. The simplified reference tissue model with 18F-fallypride PET: Choice of reference region. Mol Imaging. 2013;12(8). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103900/
Sebold M, Spitta G, Gleich T, et al. Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence. J Neural Transm (Vienna). February 2019;126(9):1127-1134. https://doi.org/10.1007/s00702-019-01985-2
Ashburner J, Friston KJ. Unified segmentation. Neuroimage. 2005;26(3):839-851. https://doi.org/10.1016/j.neuroimage.2005.02.018
Jenkinson M, Beckmann CF, Behrens TEJ, Woolrich MW, Smith SM. FSL. Neuroimage. 2012;62(2):782-790. https://doi.org/10.1016/j.neuroimage.2011.09.015
Fehr C, Yakushev I, Hohmann N, et al. Association of low striatal dopamine D2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. AJP. 2008;165(4):507-514. https://doi.org/10.1176/appi.ajp.2007.07020352
Rominger A, Cumming P, Xiong G, et al. [18F]fallypride PET measurement of striatal and extrastriatal dopamine D2/3 receptor availability in recently abstinent alcoholics. Addict Biol. 2012;17(2):490-503. https://doi.org/10.1111/j.1369-1600.2011.00355.x
Albrecht DS, Kareken DA, Yoder KK. Effects of smoking on D₂/D₃ striatal receptor availability in alcoholics and social drinkers. Brain Imaging Behav. 2013;7(3):326-334. https://doi.org/10.1007/s11682-013-9233-4
Wiers CE, Cabrera EA, Tomasi D, et al. Striatal dopamine D2/D3 receptor availability varies across smoking status. Neuropsychopharmacology. June 2017;42(12):2325-2332. https://doi.org/10.1038/npp.2017.131
Martinez D, Gil R, Slifstein M, et al. Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biol Psychiatry. 2005;58(10):779-786. https://doi.org/10.1016/j.biopsych.2005.04.044
Ravan S, Martinez D, Slifstein M, Abi-Dargham A. Molecular imaging in alcohol dependence. Handb Clin Neurol. 2014;125:293-311. https://doi.org/10.1016/B978-0-444-62619-6.00018-5
Volkow ND, Wang G-J, Fowler JS, et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res. 1996;20(9):1594-1598. https://doi.org/10.1111/j.1530-0277.1996.tb05936.x
Volkow ND, Wang G-J, Maynard L, et al. Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study. Psychiatry Res. 2002;116(3):163-172.
Volkow ND, Wang G-J, Telang F, et al. Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J Neurosci. 2007;27(46):12700-12706. https://doi.org/10.1523/JNEUROSCI.3371-07.2007
Tupala E, Hall H, Bergström K, et al. Dopamine D(2)/D(3)-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics. Mol Psychiatry. 2001;6(3):261-267. https://doi.org/10.1038/sj.mp.4000859
Tupala E, Hall H, Bergström K, et al. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse. 2003;48(4):205-211. https://doi.org/10.1002/syn.10206
Spreckelmeyer KN, Paulzen M, Raptis M, et al. Opiate-induced dopamine release is modulated by severity of alcohol dependence: an [18F]fallypride positron emission tomography study. Biol Psychiatry. 2011;70(8):770-776. https://doi.org/10.1016/j.biopsych.2011.05.035
Haber SN, Fudge JL, McFarland NR. Striatonigrostriatal pathways in Primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci. 2000;20(6):2369-2382. https://doi.org/10.1523/JNEUROSCI.20-06-02369.2000
Ikemoto S. Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev. 2007;56(1):27-78. https://doi.org/10.1016/j.brainresrev.2007.05.004
Comings DE, Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res. 2000;126:325-341. https://doi.org/10.1016/S0079-6123(00)26022-6
Schellekens AFA, Franke B, Ellenbroek B, et al. Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes. Arch Gen Psychiatry. 2012;69(4):339-348. https://doi.org/10.1001/archgenpsychiatry.2011.1335
Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW. Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3125-3135. https://doi.org/10.1098/rstb.2008.0089
Gleich T, Deserno L, Lorenz RC, et al. Prefrontal and striatal glutamate differently relate to striatal dopamine: potential regulatory mechanisms of striatal presynaptic dopamine function? J Neurosci. 2015;35(26):9615-9621. https://doi.org/10.1523/JNEUROSCI.0329-15.2015
Martinez D, Gil R, Slifstein M, et al. Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biol Psychiatry. 2005;58(10):779-786.