Intensity-modulated radiation therapy administered to a previously irradiated spine is effective and well-tolerated.
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Cauda Equina
/ radiation effects
Child
Female
Humans
Male
Middle Aged
Organs at Risk
/ radiation effects
Radiation Tolerance
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated
/ adverse effects
Re-Irradiation
/ adverse effects
Relative Biological Effectiveness
Retrospective Studies
Spinal Cord
/ radiation effects
Spinal Neoplasms
/ diagnostic imaging
Survival Rate
Time Factors
Young Adult
Intensity-modulated radiation therapy
Metastasis
Re-irradiation
Spine
Stereotactic radiation therapy
Stereotactic radiosurgery
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
ISSN: 1699-3055
Titre abrégé: Clin Transl Oncol
Pays: Italy
ID NLM: 101247119
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
27
03
2020
accepted:
23
05
2020
pubmed:
7
6
2020
medline:
28
8
2021
entrez:
7
6
2020
Statut:
ppublish
Résumé
This study sought to discern the clinical outcomes of intensity-modulated radiation therapy (IMRT) administered to the spine in patients who had undergone previous radiotherapy. A total of 81 sites of 74 patients who underwent previous radiotherapy administered to the spine or peri-spine and subsequently received IMRT for the spine were analyzed in this study. The prescribed dose of 80 Gy in a biologically effective dose (BED) of α/β = 10 (BED The median follow-up period was 10.1 (0.9-92.1) months after re-irradiation, while the median interval from the last day of the previous radiotherapy to the time of re-irradiation was 15.6 (0.4-210.1) months. Separately, the median prescript dose of re-irradiation was 78.0 (28.0-104.9) of BED Re-irradiation for the spine using IMRT seems well-tolerated. Definitive re-irradiation can be a feasible treatment option in patients with the potential for a good prognosis.
Identifiants
pubmed: 32504187
doi: 10.1007/s12094-020-02410-x
pii: 10.1007/s12094-020-02410-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
229-239Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17K16493
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