Efficacy of vardenafil in human nasal mucosa.

Dose-Response Relationship, Drug Drug Repositioning Erectile Dysfunction / drug therapy Humans In Vitro Techniques Isometric Contraction / drug effects Male Methoxamine / pharmacology Nasal Mucosa / drug effects Nasal Obstruction / diagnostic imaging Parasympatholytics Phosphodiesterase 5 Inhibitors / pharmacology Sympathomimetics / pharmacology Vardenafil Dihydrochloride / pharmacology
Human nasal mucosa Sympathetic function Vardenafil

Journal

American journal of otolaryngology
ISSN: 1532-818X
Titre abrégé: Am J Otolaryngol
Pays: United States
ID NLM: 8000029

Informations de publication

Date de publication:
Historique:
received: 01 04 2020
accepted: 23 05 2020
pubmed: 7 6 2020
medline: 20 11 2020
entrez: 7 6 2020
Statut: ppublish

Résumé

Levitra, a phosphodiesterase-5 (PDE5) inhibitor, is the trade name of vardenafil. It is applied to treatment of erectile dysfunction. PDE5 inhibitors dilate the penile blood vessels and cause prolonged erections. However, the effects of Levitra on human nasal mucosa are not yet fully explored. We examined the effectiveness of Levitra on human nasal mucosa directly in vitro by testing: 1) effect on human nasal mucosa resting tension; 2) effect on contraction caused by 10 The results showed that addition of methoxamine to the incubation medium caused the nasal mucosa to contract in a dose-dependent manner. Addition of Levitra at doses of 10 This study indicated that high concentrations of Levitra had a significant spasmolytic effect by antagonizing α-adrenoceptors. Moreover, nasal obstruction might not be relieved in patients suffering from erectile dysfunction and stuffy noses who were concomitant using α-adrenergic agonist and Levitra.

Identifiants

DOI: 10.1016/j.amjoto.2020.102561 PMID: 32504853
pubmed: 32504853
pii: S0196-0709(20)30255-6
doi: 10.1016/j.amjoto.2020.102561
pii:
doi:

Substances chimiques

Parasympatholytics 0
Phosphodiesterase 5 Inhibitors 0
Sympathomimetics 0
Vardenafil Dihydrochloride 5O8R96XMH7
Methoxamine HUQ1KC1YLI

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102561

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest No potential conflict of interest relevant to this article is reported.

Auteurs

Hsing-Won Wang (HW)

The Graduate Institute of Clinical Medicine and Department of Otolaryngology, College of Medicine, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan, Republic of China; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China. Electronic address: w0512n@ms15.hinet.net.

Li-Hsiang Cheng (LH)

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Fei-Peng Lee (FP)

The Graduate Institute of Clinical Medicine and Department of Otolaryngology, College of Medicine, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan, Republic of China. Electronic address: fplee@tmu.edu.tw.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Troubles mentaux › Dysfonctionnements sexuels psychogènes › Dysfonctionnement érectile › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction isométrique › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Composés chimiques organiques › Amines › Éthylamines › Phénéthylamines › Méthoxamine › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Muqueuse nasale › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du nez › Obstruction nasale › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents du système nerveux périphérique › Agents du système nerveux autonome › Parasympatholytiques › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la phosphodiestérase › Inhibiteurs de la phosphodiestérase-5 › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents du système nerveux périphérique › Agents du système nerveux autonome › Sympathomimétiques › Efficacy of vardenafil in human nasal mucosa.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Dichlorhydrate de vardénafil › Efficacy of vardenafil in human nasal mucosa.