Ultrasound features of fetal toxoplasmosis: A contemporary multicenter survey in 88 fetuses.
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
02
2020
revised:
16
05
2020
accepted:
23
05
2020
pubmed:
9
6
2020
medline:
26
10
2021
entrez:
8
6
2020
Statut:
ppublish
Résumé
To describe the lesions detected by prenatal ultrasound examination in congenital toxoplasmosis (CT). We retrospectively analyzed all cases of fetal infection with Toxoplasma gondii with ultrasound anomalies described by fetal medicine experts in 2009 to 2019 in 30 French centers. Eighty-eight cases of CT were included. Forty-five (51.1%) had one or more cerebral signs only, 35 (39.8%) had cerebral plus extracerebral signs and 8 (9.1%) had extracerebral signs only. The main cerebral signs were intracranial hyperechogenic nodular foci (n = 60) of which 20 were isolated, ventriculomegalies (n = 44) which generally increased during follow-up, and periventricular abscesses (n = 12). The main extracerebral signs were hepatomegaly and/or splenomegaly (n = 14), small for gestational age (n = 14), ascites (n = 14, including 2 with hydrops), and hyperechogenic bowel (n = 11). Maternal infection occurred mostly in the first or second trimester (81 cases), periconceptionally in one and in the third trimester in six cases. The first ultrasound signs were detected after a median of 7 weeks (range: 1.4; 24.0) following maternal toxoplasmosis seroconversion. While no sign was specific of CT, there were typical associations of cerebral signs with or without extracerebral signs. Detailed ultrasound examination could improve prognostic evaluation, as well as diagnosis of CT in settings lacking serological screening.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1741-1752Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' data. Lancet. 2007;369:115-122.
Kieffer F, Wallon M, Garcia P, Thulliez P, Peyron F, Franck J. Risk factors for retinochoroiditis during the first 2 years of life in infants with treated congenital toxoplasmosis. Pediatr Infect Dis J. 2008;27:27-32.
Freeman K, Tan HK, Prusa A, et al. Predictors of retinochoroiditis in children with congenital toxoplasmosis: European, prospective cohort study. Pediatrics. 2008;121:e1215-e1222.
Haute Autorité de Santé - Surveillance sérologique et prévention de la toxoplasmose et de la rubéole au cours de la grossesse et dépistage prénatal de
CNR Toxoplasmose - Centre National de Référence sur la Toxoplasmose - CHU de Reims [Internet]. Cited September 3, 2019. http://cnrtoxoplasmose.chu-reims.fr/
Robert-Gangneux F, Darde M-L. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev. 2012;25:264-296.
Hohlfeld P, MacAleese J, Capella-Pavlovski M, et al. Fetal toxoplasmosis: ultrasonographic signs: toxoplasmosis: ultrasound. Ultrasound Obstet Gynecol. 1991;1:241-244.
Malinger G, Werner H, Rodriguez Leonel JC, et al. Prenatal brain imaging in congenital toxoplasmosis. Prenat Diagn. 2011;31:881-886.
Dhombres F, Friszer S, Maurice P, et al. Prognosis of fetal parenchymal cerebral lesions without ventriculomegaly in congenital toxoplasmosis infection. Fetal Diagn Ther. 2017;41:8-14.
PLM-toxo-CAT-janvier2017.pdf [Internet]. Cited October 7, 2019. http://www.societe-francaise-neonatalogie.fr/wp-content/uploads/2017/01/PLM-toxo-CAT-janvier2017.pdf#page=1&zoom=auto,-13,842
Hohlfeld P, Daffos F, Costa JM, Thulliez P, Forestier F, Vidaud M. Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid. N Engl J Med. 1994;331:695-699.
Diagnostic biologique de la toxoplasmose acquise du sujet immunocompétent (dont la femme enceinte), la toxoplasmose congénitale (diagnostic pré- et postnatal) et la toxoplasmose oculaire [Internet]. Haute Autorité de Santé. Cited September 29, 2019. https://www.has-sante.fr/jcms/c_2653655/fr/diagnostic-biologique-de-la-toxoplasmose-acquise-du-sujet-immunocompetent-dont-la-femme-enceinte-la-toxoplasmose-congenitale-diagnostic-pre-et-postnatal-et-la-toxoplasmose-oculaire
Mandelbrot L, Kieffer F, Sitta R, et al. Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial. Am J Obstet Gynecol. 2018;219:386.e1-386.e9.
Peyron F, L'ollivier C, Mandelbrot L, et al. Maternal and congenital toxoplasmosis: diagnosis and treatment recommendations of a French multidisciplinary working group. Pathogens. 2019;8:24.
Guibaud L. Fetal cerebral ventricular measurement and ventriculomegaly: time for procedure standardization. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2009;34:127-130.
Hata T, Aoki S, Takamori H, Hata K, Murao F, Kitao M. Ultrasonographic in utero identification and measurement of the normal fetal spleen. Gynecol Obstet Invest. 1987;23:124-128.
Vintzileos AM, Neckles S, Campbell WA, Andreoli JW, Kaplan BM, Nochimson DJ. Fetal liver ultrasound measurements during normal pregnancy. Obstet Gynecol. 1985;66:477-480.
Strocker AM, Snijders RJ, Carlson DE, et al. Fetal echogenic bowel: parameters to be considered in differential diagnosis: prognosis of echogenic fetal bowel. Ultrasound Obstet Gynecol. 2000;16:519-523.
Lee AJ, Bethune M, Hiscock RJ. Placental thickness in the second trimester: a pilot study to determine the normal range. J Ultrasound Med Off J Am Inst Ultrasound Med. 2012;31:213-218.
Hedlund GL, Boyer RS. Neuroimaging of postnatal pediatric central nervous system infections. Semin Pediatr Neurol. 1999;6:299-317.
Massoud M, Duyme M, Fontanges M. French College of Fetal Sonography (CFEF), Combourieu D. [Chart for estimation of fetal weight 2014 by the French College of Fetal Sonography (CFEF)]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:80-85.
Blondiaux E, Garel C. Fetal cerebral imaging - ultrasound vs. MRI: an update. Acta Radiol. 2013;54:1046-1054.
Fallahi S, Rostami A, Nourollahpour Shiadeh M, Behniafar H, Paktinat S. An updated literature review on maternal-fetal and reproductive disorders of Toxoplasma gondii infection. J Gynecol Obstet Hum Reprod. 2018;47:133-140.
Hutson SL, Wheeler KM, McLone D, et al. Patterns of hydrocephalus caused by congenital Toxoplasma gondii infection associate with parasite genetics. Clin Infect Dis Off Publ Infect Dis Soc Am. 2015;61:1831-1834.
Abboud P, Harika G, Saniez D, et al. Ultrasonic signs of fetal toxoplasmosis. Review of the literature. J Gynecol Obstet Biol Reprod (Paris). 1995;24:733-738.
Carme B, Demar-Pierre M. Toxoplasmosis in French Guiana. Atypical (neo-)tropical features of a cosmopolitan parasitosis. Med Trop Rev Corps Sante Colon. 2006;66:495-503.
Carme B, Demar M, Ajzenberg D, Dardé ML. Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii. French Guiana Emerg Infect Dis. 2009;15:656-658.
Delhaes L, Ajzenberg D, Sicot B, et al. Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review. Prenat Diagn. 2010;30:902-905.
Malinger G, Lev D, Zahalka N, et al. Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. Am J Neuroradiol. 2003;24:28-32.
Pires P, Jungmann P, Galvão JM, et al. Neuroimaging findings associated with congenital Zika virus syndrome: case series at the time of first epidemic outbreak in Pernambuco state. Brazil Childs Nerv Syst. 2018;34:957-963.
Li X-L, Wei H-X, Zhang H, Peng H-J, Lindsay DS. A meta analysis on risks of adverse pregnancy outcomes in Toxoplasma gondii infection. PloS One. 2014;9:e97775.