Synthesis, antimicrobial evaluation, and in silico studies of quinoline-1H-1,2,3-triazole molecular hybrids.
1H-1,2,3-triazole
Antimicrobial resistance
In silico
Molecular hybridization
Quinoline
Journal
Molecular diversity
ISSN: 1573-501X
Titre abrégé: Mol Divers
Pays: Netherlands
ID NLM: 9516534
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
03
03
2020
accepted:
27
05
2020
pubmed:
9
6
2020
medline:
5
2
2022
entrez:
9
6
2020
Statut:
ppublish
Résumé
Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this regard, molecular hybridization is deemed as a viable strategy to afford multi-target-based drug candidates. Herein, we report a library of quinoline-1H-1,2,3-triazole molecular hybrids synthesized via copper(I)-catalyzed azide-alkyne [3 + 2] dipolar cycloaddition reaction (CuAAC). Antimicrobial evaluation identified compound 16 as the most active hybrid in the library with a broad-spectrum antibacterial activity at an MIC
Identifiants
pubmed: 32507981
doi: 10.1007/s11030-020-10112-3
pii: 10.1007/s11030-020-10112-3
doi:
Substances chimiques
Triazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2201-2218Subventions
Organisme : National Research Foundation
ID : 121276
Informations de copyright
© 2020. Springer Nature Switzerland AG.
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