The Effect of Cyclopentolate on Ocular Biometric Components.
Administration, Ophthalmic
Biometry
Child
Cross-Sectional Studies
Cyclopentolate
/ administration & dosage
Eye
/ anatomy & histology
Female
Humans
Male
Mydriatics
/ administration & dosage
Ophthalmic Solutions
Pupil
/ drug effects
Refraction, Ocular
/ physiology
Refractive Errors
/ diagnosis
Vision Tests
Journal
Optometry and vision science : official publication of the American Academy of Optometry
ISSN: 1538-9235
Titre abrégé: Optom Vis Sci
Pays: United States
ID NLM: 8904931
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
24
4
2021
Statut:
ppublish
Résumé
It is apparent that a variety of biometric changes are caused by different types of cycloplegic eye drops. However, these effects are inconsistent and have not been reported in different refractive groups. The purpose of this study was to determine the effect of cyclopentolate 1% on ocular biometric components in different types of refractive errors in children. This cross-sectional study was conducted on 226 eyes of 113 schoolchildren in Shahroud, northeast Iran, with a mean ± standard deviation age of 9.20 ± 1.65 years. All participants had noncycloplegic and cycloplegic objective refraction using an autorefractometer. Cycloplegia was induced using cyclopentolate 1% eye drops. Biometric measurements were made with Allegro Biograph (WaveLight AG, Erlangen, Germany) before and after administering cycloplegic drops. Mixed-effect model regression was used to analyze the data. After cycloplegia, the vitreous chamber depth (VCD) (-0.043; 95% confidence interval [CI], -0.067 to -0.019 mm), lens thickness (-0.146; 95% CI, -0.175 to -0.117 mm), axial length (-0.009; 95% CI, -0.012 to -0.006 mm), and lens power (-0.335; 95% CI, -0.463 to -0.208 D) decreased significantly, whereas the anterior chamber depth (ACD) (0.183; 95% CI, 0.164 to 0.202 mm), anterior segment length (0.036; 95% CI, 0.014 to 0.058) mm), lens central point (0.109; 95% CI, 0.094 to 0.124 mm), and pupil diameter (1.599; 95% CI, 1.482 to 1.716 mm) increased (P value for all tests, <.001). For changes in VCD and ACD, a significant interaction was observed between different types of refractive errors and cycloplegia, such that the adjusted mean change for ACD was significantly lower and for VCD was significantly higher in hyperopes compared with emmetropes. Lens center moves backward in myopes (0.17 mm) and stays the same in hyperopes under cycloplegia. According to the findings of this study, cycloplegia reduces the thickness of the crystalline lens and subsequently causes an increase in the ACD. Cycloplegia-related ocular biometric changes were different by type of refractive error.
Identifiants
pubmed: 32511166
doi: 10.1097/OPX.0000000000001524
pii: 00006324-202006000-00009
doi:
Substances chimiques
Mydriatics
0
Ophthalmic Solutions
0
Cyclopentolate
I76F4SHP7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
440-447Références
Chang SW, Lo AY, Su PF. Anterior Segment Biometry Changes with Cycloplegia in Myopic Adults. Optom Vis Sci 2016;93:12–8.
Cheng HC, Hsieh YT. Short-term Refractive Change and Ocular Parameter Changes After Cycloplegia. Optom Vis Sci 2014;91:1113–7.
Mutti DO, Zadnik K, Egashira S, et al. The Effect of Cycloplegia on Measurement of the Ocular Components. Invest Ophthalmol Vis Sci 1994;35:515–27.
Momeni-Moghaddam H, Maddah N, Wolffsohn JS, et al. The Effect of Cycloplegia on the Ocular Biometric and Anterior Segment Parameters: A Cross-sectional Study. Ophthalmol Ther 2019;8:387–95.
Raina UK, Gupta SK, Gupta A, et al. Effect of Cycloplegia on Optical Biometry in Pediatric Eyes. J Pediatr Ophthalmol Strabismus 2018;55:260–5.
Huang J, McAlinden C, Su B, et al. The Effect of Cycloplegia on the Lenstar and the IOLMaster Biometry. Optom Vis Sci 2012;89:1691–6.
Emamian MH, Hashemi H, Khabazkhoob M, et al. Cohort Profile: Shahroud Schoolchildren Eye Cohort Study (SSCECS). Int J Epidemiol 2019;48:27–27f.
Gao L, Zhuo X, Kwok AK, et al. The Change in Ocular Refractive Components After Cycloplegia in Children. Jpn J Ophthalmol 2002;46:293–8.
Harper DG. Bringing Accommodation into Focus: The Several Discoveries of the Ciliary Muscle. JAMA Ophthalmol 2014;132:645–8.
Roman F. The Discovery of Accommodation. Br J Ophthalmol 1995;79:375.
Stark L. Presbyopia in Light of Accommodation. Am J Optom Physiol Opt 1988;65:407–16.
Ben-nun J. Ciliary Muscle Morphologic Changes with Accommodation and Axial Ametropia. Invest Ophthalmol Vis Sci 2011;52:5904.
Egashira SM, Kish LL, Twelker JD, et al. Comparison of Cyclopentolate versus Tropicamide Cycloplegia in Children. Optom Vis Sci 1993;70:1019–26.
Sani RY, Hassan S, Habib SG, et al. Cycloplegic Effect of Atropine Compared with Cyclopentolate-tropicamide Combination in Children with Hypermetropia. Niger Med J 2016;57:173–7.
German EJ, Wood D, Hurst MA. Ocular Effects of Antimuscarinic Compounds: Is Clinical Effect Determined by Binding Affinity for Muscarinic Receptors or Melanin Pigment? J Ocul Pharmacol Ther 1999;15:257–69.
Owens H, Garner LF, Yap MK, et al. Age Dependence of Ocular Biometric Measurements under Cycloplegia with Tropicamide and Cyclopentolate. Clin Exp Optom 1998;81:159–62.
Fincham EF. The Accommodation Reflex and Its Stimulus. Br J Ophthalmol 1951;35:381–93.
Fincham EF. The Proportion of Ciliary Muscular Force Required for Accommodation. J Physiol 1955;128:99–112.
Kruger PB, Nowbotsing S, Aggarwala KR, et al. Small Amounts of Chromatic Aberration Influence Dynamic Accommodation. Optom Vis Sci 1995;72:656–66.
Zadnik K. The Ocular Examination: Measurements and Findings. Philadelphia, PA: W. B. Saunders; 1997.
Li SM, Iribarren R, Kang MT, et al. Corneal Power, Anterior Segment Length and Lens Power in 14-year-old Chinese Children: The Anyang Childhood Eye Study. Sci Rep 2016;6:20243.