Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria.

2-Aminopurine Bacteria / genetics Bacterial Proteins / genetics Base Sequence Binding Sites Consensus Sequence DNA, Bacterial / chemistry DNA-Binding Proteins / metabolism Epigenesis, Genetic / physiology Epigenomics Escherichia coli / metabolism Genome, Bacterial Phosphates / metabolism Salmonella enterica / genetics
ChIP-seq DNA modification DNA target selection epigenetics restriction-modification

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 06 2020
Historique:
pubmed: 11 6 2020
medline: 29 8 2020
entrez: 11 6 2020
Statut: ppublish

Résumé

Phosphorothioate (PT) DNA modifications-in which a nonbonding phosphate oxygen is replaced with sulfur-represent a widespread, horizontally transferred epigenetic system in prokaryotes and have a highly unusual property of occupying only a small fraction of available consensus sequences in a genome. Using

Identifiants

DOI: 10.1073/pnas.2002933117 PMID: 32518115 PMC: PMC7322087
pubmed: 32518115
pii: 2002933117
doi: 10.1073/pnas.2002933117
pmc: PMC7322087
doi:

Substances chimiques

Bacterial Proteins 0
DNA, Bacterial 0
DNA-Binding Proteins 0
Phosphates 0
2-Aminopurine 452-06-2
thiophosphoric acid TYM4M7EWCW

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

14322-14330

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM130376
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Xiaolin Wu (X)

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Antimicrobial Resistance Interdisciplinary Research Group, Singapore-Massachusetts Institute of Technology Alliance for Research and Technology, 138602 Singapore, Singapore.
ORCID: 0000-0001-6924-292X

Bo Cao (B)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Antimicrobial Resistance Interdisciplinary Research Group, Singapore-Massachusetts Institute of Technology Alliance for Research and Technology, 138602 Singapore, Singapore.
College of Life Sciences, Qufu Normal University, 273165 Qufu, Shandong, China.
ORCID: 0000-0002-7011-1676

Patricia Aquino (P)

Department of Biomedical Engineering, Boston University, Boston, MA 02215.
ORCID: 0000-0003-1065-4967

Tsu-Pei Chiu (TP)

Quantitative and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
Department of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089.
Department of Computer Science, University of Southern California, Los Angeles, CA 90089.

Chao Chen (C)

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.

Susu Jiang (S)

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.

Zixin Deng (Z)

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.

Shi Chen (S)

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
ORCID: 0000-0002-8965-1015

Remo Rohs (R)

Quantitative and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
Department of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089.
Department of Computer Science, University of Southern California, Los Angeles, CA 90089.
ORCID: 0000-0003-1752-1884

Lianrong Wang (L)

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China; lianrong@whu.edu.cn jgalag@bu.edu pcdedon@mit.edu.
ORCID: 0000-0003-1669-6340

James E Galagan (JE)

Department of Biomedical Engineering, Boston University, Boston, MA 02215; lianrong@whu.edu.cn jgalag@bu.edu pcdedon@mit.edu.
ORCID: 0000-0003-0542-3291

Peter C Dedon (PC)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; lianrong@whu.edu.cn jgalag@bu.edu pcdedon@mit.edu.
Antimicrobial Resistance Interdisciplinary Research Group, Singapore-Massachusetts Institute of Technology Alliance for Research and Technology, 138602 Singapore, Singapore.
Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
ORCID: 0000-0003-0011-3067

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adénine › Amino-2 purine › Epigenetic competition reveals...
questionsmedicales.fr › Bactéries › Epigenetic competition reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Epigenetic competition reveals...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Epigenetic competition reveals...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Epigenetic competition reveals...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Séquence conservée › Séquence consensus › Epigenetic competition reveals...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN bactérien › Epigenetic competition reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Epigenetic competition reveals...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic competition reveals...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Epigenetic competition reveals...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Epigenetic competition reveals...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Epigenetic competition reveals...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Epigenetic competition reveals...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Salmonella › Salmonella enterica › Epigenetic competition reveals...