A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.

Aged DNA, Bacterial / genetics Evolution, Molecular Genetic Variation Genome, Bacterial Genomics Genotype Humans Likelihood Functions Limit of Detection Male Mutation Mycobacterium tuberculosis / classification Phenotype Phylogeny Rifampin / pharmacology Rwanda Tuberculosis, Multidrug-Resistant / microbiology Uganda

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
09 06 2020

Historique:

received: 21 01 2020

accepted: 13 05 2020

entrez: 11 6 2020

pubmed: 11 6 2020

medline: 28 8 2020

Statut: epublish

Résumé

The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.

Identifiants

DOI: 10.1038/s41467-020-16626-6 PMID: 32518235 PMC: PMC7283319

pubmed: 32518235

doi: 10.1038/s41467-020-16626-6

pii: 10.1038/s41467-020-16626-6

pmc: PMC7283319

doi:

Substances chimiques

DNA, Bacterial 0

Rifampin VJT6J7R4TR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

2917

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