Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study.
Antigens, Neoplasm
/ genetics
Coronary Disease
/ blood
Diabetes Mellitus, Type 2
/ blood
Diet, Fat-Restricted
Diet, Mediterranean
Female
Gene Expression Regulation
Glycation End Products, Advanced
/ blood
Humans
Insulin Resistance
Kaplan-Meier Estimate
Male
Middle Aged
Mitogen-Activated Protein Kinases
/ genetics
Pyruvaldehyde
/ blood
Receptor for Advanced Glycation End Products
/ genetics
Treatment Outcome
Mediterranean diet
advanced glycation end products
type 2 diabetes mellitus
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
18
12
2019
revised:
01
06
2020
pubmed:
13
6
2020
medline:
28
9
2021
entrez:
13
6
2020
Statut:
ppublish
Résumé
It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. Patients from CORDIOPREV study, all with previous cardiovascular events, with T2DM at the beginning of the study are included. Patients are randomized to a Mediterranean or a low-fat diet for five years. No different diabetes remission rates are found among diets. Serum methylglioxal (MG) and carboximethyllysine (CML), levels dietary AGE, as well as gene expression of AGER1 and RAGE are measured. Serum MG decreases only after the consumption of the Mediterranean diet. Moreover, a COX regression analysis shows that each SD decrease in the MG, occurring after the Mediterranean diet, increases the probability of T2DM remission with HR:2.56(1.02-6.25) and p = 0.046 and each SD increase in disposition index at baseline increases the probability of remission with HR:1.94(1.32-2.87) and p = 0.001. It is demonstrated that the reduction of serum AGEs levels and the modulation of its metabolism, occurring after the consumption of a Mediterranean diet, might be involved in the molecular mechanism underlying the T2DM remission of newly diagnosed patients with coronary heart disease.
Identifiants
pubmed: 32529753
doi: 10.1002/mnfr.201901290
doi:
Substances chimiques
AGER protein, human
0
Antigens, Neoplasm
0
Glycation End Products, Advanced
0
Receptor for Advanced Glycation End Products
0
Pyruvaldehyde
722KLD7415
MOK protein, human
EC 2.7.11.22
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1901290Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
S. L. James, D. Abate, K. H. Abate, S. M. Abay, C. Abbafati, N. Abbasi, H. Abbastabar, F. Abd-Allah, J. Abdela, A. Abdelalim, I. Abdollahpour, R. S. Abdulkader, Z. Abebe, S. F. Abera, O. Z. Abil, H. N. Abraha, L. J. Abu-Raddad, N. M. E. Abu-Rmeileh, M. M. K. Accrombessi, D. Acharya, P. Acharya, I. N. Ackerman, A. A. Adamu, O. M. Adebayo, V. Adekanmbi, O. O. Adetokunboh, M. G. Adib, J. C. Adsuar, K. A. Afanvi, M. Afarideh, et al., Lancet 2018, 392, 1789.
World Health Organization, WHO recommendations on antenatal care for a positive pregnancy experience, World Health Organization, Geneva 2016.
M. Ezzati, E. Riboli, N. Engl. J. Med. 2013, 369, 954.
H. Kolb, S. Martin, BMC Med. 2017, 15, 131.
R. M. van Dam, Eur. J. Epidemiol. 2003, 18, 1115.
K. Esposito, C. M. Kastorini, D. B. Panagiotakos, D. Giugliano, Metab. Syndr. Relat. Disord. 2010, 8, 471.
S. H. Ley, O. Hamdy, V. Mohan, F. B. Hu, Lancet 2014, 383, 1999.
O. Ajala, P. English, J. Pinkney, Am. J. Clin. Nutr. 2013, 97, 505.
R. Casas, S. Castro-Barquero, R. Estruch, E. Sacanella, Int. J. Mol. Sci. 2018, 19, 3988.
E. L. Lim, K. G. Hollingsworth, B. S. Aribisala, M. J. Chen, J. C. Mathers, R. Taylor, Diabetologia 2011, 54, 2506.
S. Steven, K. G. Hollingsworth, A. Al-Mrabeh, L. Avery, B. Aribisala, M. Caslake, R. Taylor, Diabetes Care 2016, 39, 808.
K. Esposito, M. I. Maiorino, M. Petrizzo, G. Bellastella, D. Giugliano, Diabetes Care 2014, 37, 1824.
K. Esposito, M. I. Maiorino, G. Bellastella, D. B. Panagiotakos, D. Giugliano, Endocrine 2017, 56, 27.
K. Nowotny, T. Jung, A. Hohn, D. Weber, T. Grune, Biomolecules 2015, 5, 194.
M. Fournet, F. Bonte, A. Desmouliere, Aging Dis. 2018, 9, 880.
S. Y. Goh, M. E. Cooper, J. Clin. Endocrinol. Metab. 2008, 93, 1143.
J. Uribarri, W. Cai, O. Sandu, M. Peppa, T. Goldberg, H. Vlassara, Ann. N. Y. Acad. Sci. 2005, 1043, 461.
J. Uribarri, S. Woodruff, S. Goodman, W. Cai, X. Chen, R. Pyzik, A. Yong, G. E. Striker, H. Vlassara, J. Am. Dietetic Assoc. 2010, 110, 911.
J. Uribarri, W. Cai, M. Ramdas, S. Goodman, R. Pyzik, X. Chen, L. Zhu, G. E. Striker, H. Vlassara, Diabetes Care 2011, 34, 1610.
J. Lopez-Moreno, G. M. Quintana-Navarro, A. Camargo, R. Jimenez-Lucena, J. Delgado-Lista, C. Marin, F. J. Tinahones, G. E. Striker, H. M. Roche, P. Perez-Martinez, J. Lopez-Miranda, E. M. Yubero-Serrano, Mol. Nutr. Food Res. 2017, 61, 1601029.
J. Lopez-Moreno, G. M. Quintana-Navarro, J. Delgado-Lista, A. Garcia-Rios, N. Delgado-Casado, A. Camargo, P. Perez-Martinez, G. E. Striker, F. J. Tinahones, F. Perez-Jimenez, J. Lopez-Miranda, E. M. Yubero-Serrano, J. Am. Geriat. Soc. 2016, 64, 901.
R. Taylor, A. Al-Mrabeh, S. Zhyzhneuskaya, C. Peters, A. C. Barnes, B. S. Aribisala, K. G. Hollingsworth, J. C. Mathers, N. Sattar, M. E. J. Lean, Cell Metab. 2018, 28, 667.
S. Steven, P. E. Carey, P. K. Small, R. Taylor, Diabet. Med. 2015, 32, 47.
M. E. Lean, W. S. Leslie, A. C. Barnes, N. Brosnahan, G. Thom, L. McCombie, C. Peters, S. Zhyzhneuskaya, A. Al-Mrabeh, K. G. Hollingsworth, A. M. Rodrigues, L. Rehackova, A. J. Adamson, F. F. Sniehotta, J. C. Mathers, H. M. Ross, Y. McIlvenna, R. Stefanetti, M. Trenell, P. Welsh, S. Kean, I. Ford, A. McConnachie, N. Sattar, R. Taylor, Lancet 2018, 391, 541.
E. Ferrannini, G. Mingrone, Diabetes Care 2009, 32, 514.
M. Uusitupa, Lancet 2018, 391, 515.
J. Lindstrom, M. Peltonen, J. G. Eriksson, P. Ilanne-Parikka, S. Aunola, S. Keinanen-Kiukaanniemi, M. Uusitupa, J. Tuomilehto, Diabetologia 2013, 56, 284.
J. Frijhoff, P. G. Winyard, N. Zarkovic, S. S. Davies, R. Stocker, D. Cheng, A. R. Knight, E. L. Taylor, J. Oettrich, T. Ruskovska, A. C. Gasparovic, A. Cuadrado, D. Weber, H. E. Poulsen, T. Grune, H. H. Schmidt, P. Ghezzi, Antioxid. Redox Signaling 2015, 23, 1144.
F. Giacco, M. Brownlee, Circ. Res. 2010, 107, 1058.
E. J. Henriksen, M. K. Diamond-Stanic, E. M. Marchionne, Free Rad. Biol. Med. 2011, 51, 993.
J. L. Leahy, Arch. Med. Res. 2005, 36, 197.
H. Vlassara, J. Uribarri, Curr. Diabetes Rep. 2014, 14, 453.
K. C. Tan, S. W. Shiu, Y. Wong, X. Tam, Diabetes/Metab. Res. Rev. 2011, 27, 488.
A. S. Cheng, Y. H. Cheng, C. Y. Lee, C. Y. Chung, W. C. Chang, Nutrients 2015, 7, 2850.
J. You, Z. Wang, S. Xu, W. Zhang, Q. Fang, H. Liu, L. Peng, T. Deng, J. Lou, J. Diabetes Res. 2016, 2016, 9073037.
R. Blanco-Rojo, J. F. Alcala-Diaz, S. Wopereis, P. Perez-Martinez, G. M. Quintana-Navarro, C. Marin, J. M. Ordovas, B. van Ommen, F. Perez-Jimenez, J. Delgado-Lista, J. Lopez-Miranda, Diabetologia 2016, 59, 67.
J. Delgado-Lista, P. Perez-Martinez, A. Garcia-Rios, J. F. Alcala-Diaz, A. I. Perez-Caballero, F. Gomez-Delgado, F. Fuentes, G. Quintana-Navarro, F. Lopez-Segura, A. M. Ortiz-Morales, N. Delgado-Casado, E. M. Yubero-Serrano, A. Camargo, C. Marin, F. Rodriguez-Cantalejo, P. Gomez-Luna, J. M. Ordovas, J. Lopez-Miranda, F. Perez-Jimenez, Am. Heart J. 2016, 177, 42.
American Diabetes Association, Diabetes Care 2014, 37, S81.
P. Aschner, Diabetes Res. Clin. Pract. 2017, 132, 169.
J. B. Buse, S. Caprio, W. T. Cefalu, A. Ceriello, S. Del Prato, S. E. Inzucchi, S. McLaughlin, G. L. Phillips, 2nd, R. P. Robertson, F. Rubino, R. Kahn, M. S. Kirkman, Diabetes Care 2009, 32, 2133.
G. M. Quintana-Navarro, J. F. Alcala-Diaz, J. Lopez-Moreno, I. Perez-Corral, A. Leon-Acuna, J. D. Torres-Pena, O. A. Rangel-Zuniga, A. P. A. de Larriva, A. Corina, A. Camargo, E. M. Yubero-Serrano, F. Rodriguez-Cantalejo, A. Garcia-Rios, R. M. Luque, J. M. Ordovas, P. Perez-Martinez, J. Lopez-Miranda, J. Delgado-Lista, Eur. J. Nutr. 2019.
M. Matsuda, R. A. DeFronzo, Diabetes Care 1999, 22, 1462.
I. Roncero-Ramos, R. Jimenez-Lucena, J. F. Alcala-Diaz, C. Vals-Delgado, A. P. Arenas-Larriva, O. A. Rangel-Zuniga, A. Leon-Acuna, M. M. Malagon, J. Delgado-Lista, P. Perez-Martinez, J. M. Ordovas, A. Camargo, J. Lopez-Miranda, J. Nutr. Biochem. 2018, 62, 247.
P. J. Thornalley, General Pharmacol. Vascul. Syst. 1996, 27, 565.
S. Arsov, R. Graaff, W. van Oeveren, B. Stegmayr, A. Sikole, G. Rakhorst, A. J. Smit, Clin. Chem. Lab. Med. 2014, 52, 11.
W. Cai, Q. D. Gao, L. Zhu, M. Peppa, C. He, H. Vlassara, Mol. Med. 2002, 8, 337.
W. Cai, M. Ramdas, L. Zhu, X. Chen, G. E. Striker, H. Vlassara, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 15888.
H. Vlassara, W. Cai, S. Goodman, R. Pyzik, A. Yong, X. Chen, L. Zhu, T. Neade, M. Beeri, J. M. Silverman, L. Ferrucci, L. Tansman, G. E. Striker, J. Uribarri, J. Clin. Endocrinol. Metab. 2009, 94, 4483.