Nisin and acid resistance in Salmonella is enhanced by N-dodecanoyl-homoserine lactone.

4-Butyrolactone / analogs & derivatives Homoserine Nisin / pharmacology Quorum Sensing Salmonella enteritidis / genetics
Acid stress N-dodecanoyl-homoserine lactone Nisin Quorum sensing Salmonella

Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 21 04 2020
revised: 02 06 2020
accepted: 03 06 2020
pubmed: 14 6 2020
medline: 22 6 2021
entrez: 14 6 2020
Statut: ppublish

Résumé

Salmonella is a foodborne pathogen that can develop resistance to different stresses, which is essential for successful infection of the host. Some genes directly related to acid resistance are also involved in cationic peptide resistance in Gram-negative bacteria and could be under the control of quorum sensing (QS) mediated by autoinducer 1, known as acyl-homoserine lactone. Here, we investigated the influence of autoinducer 1, N-dodecanoyl-homoserine lactone (C12-HSL) on the resistance of Salmonella enterica subspecies enterica serovar Enteritidis to nisin and acid stress. Salmonella cells growing in anaerobic tryptic soy agar (TSB) at a pH of 7.0 for 7 h were submitted to acid stress at a pH of 4.5 in the presence and absence of nisin and were either supplemented or not with C12-HSL. Viable cell counts, gene expression, membrane charge alterations, fatty acid composition, and intracellular content leakage were observed. The autoinducer C12-HSL increased nisin resistance and survival at a pH of 4.5 in Salmonella. Also, C12-HSL increased the expression of the genes, phoP, phoQ, pmrA, and pmrB, which are involved with antimicrobial and acid resistance. The positive charge on the cell surface and concentration of cyclopropane fatty acid of the cellular membrane were increased in the presence of C12-HSL under acidic conditions, whereas membrane fluidity decreased. The loss of K

Identifiants

DOI: 10.1016/j.micpath.2020.104320 PMID: 32534181
pubmed: 32534181
pii: S0882-4010(20)30686-0
doi: 10.1016/j.micpath.2020.104320
pii:
doi:

Substances chimiques

homoserine lactone 1192-20-7
Nisin 1414-45-5
Homoserine 6KA95X0IVO
4-Butyrolactone OL659KIY4X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104320

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Leonardo Luiz de Freitas (L)

Department of Microbiology, Universidade Federal de Viçosa (UFV), Av. Peter Henry Rolfs, S/N, Viçosa, MG, Brazil.

Clarissa Isabela Aparecida Dos Santos (CI)

Department of Microbiology, Universidade Federal de Viçosa (UFV), Av. Peter Henry Rolfs, S/N, Viçosa, MG, Brazil.

Deisy Guimarães Carneiro (DG)

Department of Microbiology, Universidade Federal de Viçosa (UFV), Av. Peter Henry Rolfs, S/N, Viçosa, MG, Brazil.

Maria Cristina Dantas Vanetti (MC)

Department of Microbiology, Universidade Federal de Viçosa (UFV), Av. Peter Henry Rolfs, S/N, Viçosa, MG, Brazil. Electronic address: mvanetti@ufv.br.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Furanes › 4-Butyrolactone › Nisin and acid resistance in Salmonella is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Homosérine › Nisin and acid resistance in Salmonella is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Bactériocines › Nisine › Nisin and acid resistance in Salmonella is...
questionsmedicales.fr › Phénomènes microbiologiques › Interactions microbiennes › Détection du quorum › Nisin and acid resistance in Salmonella is...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Salmonella › Salmonella enterica › Salmonella enteritidis › Nisin and acid resistance in Salmonella is...