Novel biomarkers for the management of chronic hepatitis B.
Alpha-fetoprotein
Hepatitis B core-related antigen
Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein
Mac 2-binding protein glycan isomer
Protein induced by vitamin K absence or antagonist-II
Journal
Clinical and molecular hepatology
ISSN: 2287-285X
Titre abrégé: Clin Mol Hepatol
Pays: Korea (South)
ID NLM: 101586730
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
11
02
2020
accepted:
13
04
2020
pubmed:
17
6
2020
medline:
24
6
2021
entrez:
16
6
2020
Statut:
ppublish
Résumé
Hepatitis B virus (HBV) cannot be eliminated completely from infected hepatocytes because of the presence of intrahepatic covalently closed circular DNA (cccDNA). As chronic hepatitis B (CHB) can progress to cirrhosis and hepatocellular carcinoma (HCC), it is important to manage CHB to prevent HCC development in high-risk patients with high viral replicative activity or advanced fibrosis. Serum biomarkers are noninvasive and valuable for the management of CHB. Hepatitis B core-related antigen (HBcrAg) correlates with serum HBV DNA and intrahepatic cccDNA. In CHB patients with undetectable serum HBV DNA or loss of HBsAg, HBcrAg still can be detected and the decrease in HBcrAg levels is significantly associated with hopeful outcomes. Therefore, HBcrAg can predict HCC occurrence or recurrence. Measurement of the Mac-2 binding protein glycosylation isomer (M2BPGi) has been introduced for the evaluation of liver fibrosis. Because elevated M2BPGi in CHB is related to liver fibrosis and the prediction of HCC development, monitoring its progression is essential. Because alpha fetoprotein (AFP) has insufficient sensitivity and specificity for early-stage HCC, a combination of AFP plus protein induced by vitamin K absence factor II, or AFP plus Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein might improve the diagnosis of HCC development. Additionally, Dickkopf-1 and circulating immunoglobulin G antibodies are the novel markers to diagnose HCC or assess HCC prognosis. This review provides an overview of novel HBV biomarkers used for the management of intrahepatic viral replicative activity, liver fibrosis, and HCC development.
Identifiants
pubmed: 32536045
pii: cmh.2020.0032
doi: 10.3350/cmh.2020.0032
pmc: PMC7364351
doi:
Substances chimiques
Antigens, Neoplasm
0
Antiviral Agents
0
Biomarkers
0
DNA, Viral
0
Hepatitis B Core Antigens
0
Membrane Glycoproteins
0
TAA90K protein, human
0
alpha-Fetoproteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-279Références
Microb Cell. 2016 Sep 05;3(9):420-437
pubmed: 28357379
Liver Int. 2017 Jul;37(7):995-1001
pubmed: 27992681
Aliment Pharmacol Ther. 2016 Jun;43(12):1253-61
pubmed: 27117732
Clin Liver Dis. 2019 Aug;23(3):535-555
pubmed: 31266626
Cancer Manag Res. 2018 Jul 10;10:1947-1958
pubmed: 30022853
Hepatol Res. 2019 Mar;49(3):271-283
pubmed: 30358027
J Gastroenterol. 2018 Jul;53(7):883-889
pubmed: 29288305
Gastroenterology. 2006 Mar;130(3):678-86
pubmed: 16530509
Gastroenterology. 2010 Feb;138(2):493-502
pubmed: 19852963
Semin Liver Dis. 2013 May;33(2):103-12
pubmed: 23749666
Clin Microbiol Infect. 2014 Nov;20(11):1173-80
pubmed: 24975365
J Clin Microbiol. 2007 Dec;45(12):3942-7
pubmed: 17942661
Hepatol Res. 2006 Dec;36(4):272-6
pubmed: 16971173
Liver Int. 2017 Jan;37 Suppl 1:40-44
pubmed: 28052637
Scand J Gastroenterol. 2016 Sep;51(9):1133-7
pubmed: 27161933
World J Clin Cases. 2019 Jun 26;7(12):1367-1382
pubmed: 31363465
Clin Res Hepatol Gastroenterol. 2019 Jun;43(3):301-309
pubmed: 30497844
World J Hepatol. 2018 Sep 27;10(9):603-611
pubmed: 30310538
J Cancer Res Ther. 2017;13(5):813-816
pubmed: 29237909
Liver Int. 2017 Jan;37(1):35-44
pubmed: 27300763
Liver Int. 2017 Jun;37(6):879-887
pubmed: 27973711
Hepatol Res. 2018 Dec;48(13):1131-1139
pubmed: 30030872
Hepatol Int. 2011 Mar 25;5(4):918-926
pubmed: 21484119
Genes (Basel). 2018 Sep 27;9(10):
pubmed: 30262738
Clin Gastroenterol Hepatol. 2009 Jan;7(1):104-13
pubmed: 18849011
Liver Cancer. 2013 Aug;2(3-4):151-2
pubmed: 24400219
Hepatol Res. 2018 Oct;48(11):872-881
pubmed: 29732647
J Gastroenterol. 2017 Feb;52(2):245-252
pubmed: 27349650
Semin Liver Dis. 2006 Nov;26(4):385-90
pubmed: 17051452
Liver Int. 2006 Feb;26(1):90-6
pubmed: 16420514
Clin Chim Acta. 2001 Nov;313(1-2):15-9
pubmed: 11694234
J Infect Dis. 2016 Apr 1;213(7):1096-106
pubmed: 26621908
Clin Microbiol Infect. 2018 Mar;24(3):306.e7-306.e13
pubmed: 28750917
Hepatol Commun. 2019 Feb 08;3(4):493-503
pubmed: 30976740
J Clin Microbiol. 2002 Feb;40(2):439-45
pubmed: 11825954
Gastroenterology. 2019 Feb;156(3):635-646.e9
pubmed: 30342034
Gastroenterol Hepatol (N Y). 2017 Dec;13(12):751-753
pubmed: 29339953
J Viral Hepat. 2004 Mar;11(2):97-107
pubmed: 14996343
Antivir Ther. 2010;15 Suppl 3:3-14
pubmed: 21041899
BMC Cancer. 2008 Jul 18;8:200
pubmed: 18638391
Aliment Pharmacol Ther. 2018 Nov;48(10):1128-1137
pubmed: 30306612
J Biol Chem. 2005 Jun 10;280(23):21713-9
pubmed: 15814524
Gastroenterology. 2009 Jul;137(1):110-8
pubmed: 19362088
Anticancer Res. 2017 Sep;37(9):4881-4888
pubmed: 28870909
Hepatol Res. 2018 Jun;48(7):521-528
pubmed: 29316028
Expert Rev Proteomics. 2015;12(6):683-93
pubmed: 26394846
Case Rep Gastroenterol. 2017 Mar 21;11(1):142-147
pubmed: 28611567
Clin Chim Acta. 2018 Nov;486:237-244
pubmed: 30025756
Medicine (Baltimore). 2017 Mar;96(11):e5811
pubmed: 28296720
Hepatology. 2014 Nov;60(5):1563-70
pubmed: 25042054
Liver Cancer. 2015 Mar;4(2):126-36
pubmed: 26020034
Aliment Pharmacol Ther. 2018 Jan;47(1):43-54
pubmed: 29035003
J Viral Hepat. 2017 Aug;24(8):654-661
pubmed: 28185363
J Hepatol. 2016 Jul;65(1):48-56
pubmed: 27034253
Oncology. 2011;81 Suppl 1:61-5
pubmed: 22212938
PLoS One. 2016 Mar 17;11(3):e0151069
pubmed: 26986465
J Gastroenterol. 2015 Jan;50(1):76-84
pubmed: 24603981
Hepatol Res. 2011 Nov;41(11):1036-45
pubmed: 21883741
Lab Med. 2020 Mar 20;:
pubmed: 32195537
J Viral Hepat. 2018 Aug;25(8):886-893
pubmed: 29532589
Liver Int. 2016 Jun;36(6):827-36
pubmed: 26678018
Hepatol Res. 2019 Jan;49(1):51-63
pubmed: 30350374
World J Gastroenterol. 2015 Oct 7;21(37):10573-83
pubmed: 26457017
Hepatol Res. 2018 Feb;48(3):E240-E251
pubmed: 28865403
Lancet Oncol. 2012 Aug;13(8):817-26
pubmed: 22738799
Ann Surg Oncol. 2009 Oct;16(10):2795-804
pubmed: 19669841
World J Gastroenterol. 2019 Mar 21;25(11):1398-1408
pubmed: 30918432
J Hepatol. 2017 Feb;66(2):275-281
pubmed: 27639844
Vopr Med Khim. 1964 Jan-Feb;10:90-1
pubmed: 14207501
J Formos Med Assoc. 2015 Oct;114(10):901-9
pubmed: 26184565
J Hepatol. 2019 Apr;70(4):615-625
pubmed: 30529504
J Gastroenterol. 2015 Jul;50(7):776-84
pubmed: 25326152
Medicine (Baltimore). 2016 Apr;95(16):e3372
pubmed: 27100421
Dis Markers. 2018 Oct 4;2018:8906023
pubmed: 30402170
Am J Gastroenterol. 2016 Dec;111(12):1788-1795
pubmed: 27644733
JAMA. 2006 Jan 4;295(1):65-73
pubmed: 16391218
Sci Rep. 2013;3:1065
pubmed: 23323209
Hepatol Res. 2017 Feb;47(2):226-233
pubmed: 27029022
J Hepatol. 2013 Mar;58(3):427-33
pubmed: 23123221
Gastroenterology. 2010 May;138(5):1747-54
pubmed: 20114048
Hepatology. 2017 Oct;66(4):1296-1313
pubmed: 28762522
Clin Mol Hepatol. 2019 Sep;25(3):245-263
pubmed: 30759967
Tumour Biol. 2014 Apr;35(4):3145-54
pubmed: 24258111
Sci Rep. 2017 Oct 30;7(1):14352
pubmed: 29085039
Med Oncol. 2015 Mar;32(3):59
pubmed: 25652109
Int J Mol Sci. 2016 Dec 20;17(12):
pubmed: 27999409
J Viral Hepat. 2016 Dec;23(12):977-984
pubmed: 27476460
J Viral Hepat. 2003 Jul;10(4):324-30
pubmed: 12823601
J Gastroenterol. 2016 Aug;51(8):830-9
pubmed: 26687058
World J Gastroenterol. 2016 Jan 7;22(1):262-74
pubmed: 26755875
Oncotarget. 2017 Jul 18;8(29):47507-47517
pubmed: 28537900
Hepatol Res. 2017 Jul;47(8):747-754
pubmed: 27577976
J Hepatol. 2015 Apr;62(4):848-54
pubmed: 25450201
Hepatol Res. 2019 Oct;49(10):1109-1113
pubmed: 31336394
Biochim Biophys Acta. 2002 Apr 24;1586(3):287-98
pubmed: 11997080
Turk J Gastroenterol. 2016 Jul;27(4):375-81
pubmed: 27458854
Gastroenterology. 2019 Dec;157(6):1518-1529.e3
pubmed: 31470004
Clin Infect Dis. 2020 Mar 17;70(7):1442-1452
pubmed: 31102406
Ther Adv Med Oncol. 2019 Sep 06;11:1758835919869120
pubmed: 31523283
Hepatology. 2019 May;69(5):1983-1994
pubmed: 30153338
Sci Rep. 2020 Mar 3;10(1):3925
pubmed: 32127619
Inflamm Bowel Dis. 2019 Jun 18;25(7):1271-1276
pubmed: 30624658
Int J Mol Sci. 2020 Jan 31;21(3):
pubmed: 32023902
Antivir Ther. 2008;13(1):57-66
pubmed: 18389899
Ann Surg Oncol. 2012 Jun;19(6):2027-34
pubmed: 22203184
World J Gastroenterol. 2013 Oct 21;19(39):6515-22
pubmed: 24151375
Hepatol Res. 2014 Jan;44 Suppl S1:1-58
pubmed: 24397839
Hepatology. 2018 Apr;67(4):1560-1599
pubmed: 29405329
Onco Targets Ther. 2019 Dec 02;12:10487-10493
pubmed: 31819529
Int J Cancer. 2006 Jun 15;118(12):3030-44
pubmed: 16404738
Hepatol Res. 2015 Dec;45(12):1195-202
pubmed: 25594111
Clin Microbiol Infect. 2015 Jun;21(6):606.e1-10
pubmed: 25700889
Eur J Gastroenterol Hepatol. 1999 Dec;11(12):1387-92
pubmed: 10654799
Oncol Rep. 2016 Aug;36(2):613-25
pubmed: 27278244
Clin Microbiol Infect. 2017 Nov;23(11):860-867
pubmed: 28288829
Chin Med J (Engl). 2016 20th Sep;129(18):2212-9
pubmed: 27625094
Aliment Pharmacol Ther. 2019 Jan;49(1):107-115
pubmed: 30450681
Medicine (Baltimore). 2016 Apr;95(14):e3328
pubmed: 27057911
Hepatol Int. 2012 Mar 13;7(1):98-105
pubmed: 24014110
Genes (Basel). 2019 May 09;10(5):
pubmed: 31075974
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
Gastroenterol Hepatol (N Y). 2018 Jun;14(6):384-386
pubmed: 30166953
Panminerva Med. 2017 Dec;59(4):283-289
pubmed: 28650134
J Med Virol. 2009 Jan;81(1):27-33
pubmed: 19031469
J Hepatol. 2015 May;62(5):1092-9
pubmed: 25445399
Aliment Pharmacol Ther. 2019 Feb;49(4):457-471
pubmed: 30663078
Scand J Gastroenterol. 2018 Jun;53(6):734-740
pubmed: 29667463
J Biol Chem. 1999 Jul 2;274(27):19465-72
pubmed: 10383463
Liver Cancer. 2013 Jan;2(1):31-9
pubmed: 24159594
World J Hepatol. 2016 Apr 8;8(10):471-84
pubmed: 27057305
Hepatol Int. 2016 Jan;10(1):99-101
pubmed: 26732689
Liver Int. 2016 Apr;36(4):580-7
pubmed: 26503910
Cancer. 2001 Feb 1;91(3):561-9
pubmed: 11169939
PLoS One. 2019 Feb 22;14(2):e0212559
pubmed: 30794632
Hepatology. 2003 Mar;37(3):520-7
pubmed: 12601348
Dig Dis Sci. 2007 Mar;52(3):776-82
pubmed: 17253135
Hepatology. 2002 Aug;36(2):410-7
pubmed: 12143050
Liver Cancer. 2014 Mar;3(1):41-52
pubmed: 24804176
Clin Mol Hepatol. 2020 Jan;26(1):33-44
pubmed: 31243939
Hepatol Res. 2007 Aug;37(8):661-6
pubmed: 17584261
Clin Gastroenterol Hepatol. 2016 Oct;14(10):1481-1489.e5
pubmed: 26872398