Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product
8-Hydroxy-2'-Deoxyguanosine
/ metabolism
Adenosine Triphosphate
/ metabolism
Aldehydes
/ toxicity
Animals
Cell Survival
/ drug effects
Cells, Cultured
Coffee
/ toxicity
Cooking
DNA Damage
Dose-Response Relationship, Drug
Furans
/ toxicity
Hepatocytes
/ drug effects
Hot Temperature
Humans
Oxidative Stress
/ drug effects
Protein Carbamylation
/ drug effects
Rats
Seeds
/ toxicity
Species Specificity
Time Factors
Furan
cis-2-butene-1,4-dial
coffee
hepatocytes
toxicity
Journal
Toxicology mechanisms and methods
ISSN: 1537-6524
Titre abrégé: Toxicol Mech Methods
Pays: England
ID NLM: 101134521
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
pubmed:
17
6
2020
medline:
1
4
2021
entrez:
17
6
2020
Statut:
ppublish
Résumé
Coffee is the most popular hot beverage and caffeine is the most used psychoactive drug in the world. Roasting of coffee beans leads to the generation of minute quantities of undesirable compounds, such as furan. It is now thought that the toxicity of furan derives from its processing by CYP450 family of detoxifying enzymes, leading to the formation of
Identifiants
pubmed: 32544017
doi: 10.1080/15376516.2020.1780361
doi:
Substances chimiques
Aldehydes
0
Coffee
0
Furans
0
malealdehyde
2363-83-9
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Adenosine Triphosphate
8L70Q75FXE
furan
UC0XV6A8N9
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM