Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
angiotensin II
dipeptidyl peptidase 3 (DPP3)
kidney function
metalloprotease
mouse
oxidative stress
peptidase
reactive oxygen species (ROS)
renal physiology
renin angiotensin system
sex-specific difference
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
02 10 2020
02 10 2020
Historique:
received:
05
05
2020
revised:
12
06
2020
pubmed:
18
6
2020
medline:
4
2
2021
entrez:
18
6
2020
Statut:
ppublish
Résumé
Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent hydrolase involved in degrading oligopeptides with 4-12 amino acid residues. It has been associated with several pathophysiological processes, including blood pressure regulation, pain signaling, and cancer cell defense against oxidative stress. However, the physiological substrates and the cellular pathways that are potentially targeted by DPP3 to mediate these effects remain unknown. Here, we show that global DPP3 deficiency in mice (DPP3
Identifiants
pubmed: 32546481
pii: S0021-9258(17)49823-1
doi: 10.1074/jbc.RA120.014183
pmc: PMC7535908
pii:
doi:
Substances chimiques
Angiotensins
0
Reactive Oxygen Species
0
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
EC 3.4.14.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13711-13723Informations de copyright
© 2020 Jha et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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