Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.

Animals Brain-Derived Neurotrophic Factor / metabolism Epidermis / innervation Female Male Membrane Glycoproteins / genetics Merkel Cells / physiology Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Protein-Tyrosine Kinases / genetics Signal Transduction Touch / physiology Touch Perception / physiology

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
19 06 2020
Historique:
received: 12 02 2020
accepted: 28 04 2020
entrez: 20 6 2020
pubmed: 20 6 2020
medline: 9 7 2020
Statut: ppublish

Résumé

Meissner corpuscles are mechanosensory end organs that densely occupy mammalian glabrous skin. We generated mice that selectively lacked Meissner corpuscles and found them to be deficient in both perceiving the gentlest detectable forces acting on glabrous skin and fine sensorimotor control. We found that Meissner corpuscles are innervated by two mechanoreceptor subtypes that exhibit distinct responses to tactile stimuli. The anatomical receptive fields of these two mechanoreceptor subtypes homotypically tile glabrous skin in a manner that is offset with respect to one another. Electron microscopic analysis of the two Meissner afferents within the corpuscle supports a model in which the extent of lamellar cell wrappings of mechanoreceptor endings determines their force sensitivity thresholds and kinetic properties.

Identifiants

DOI: 10.1126/science.abb2751 PMID: 32554568 PMC: PMC7354383
pubmed: 32554568
pii: 368/6497/eabb2751
doi: 10.1126/science.abb2751
pmc: PMC7354383
mid: NIHMS1606072
pii:
doi:

Substances chimiques

Bdnf protein, mouse 0
Brain-Derived Neurotrophic Factor 0
Membrane Glycoproteins 0
Ntrk2 protein, mouse EC 2.7.10.1
Protein-Tyrosine Kinases EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : R35 NS097344
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS105324
Pays : United States
Organisme : NINDS NIH HHS
ID : R00 NS101057
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089521
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS101057
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Nicole L Neubarth (NL)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0003-3781-5599

Alan J Emanuel (AJ)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-6479-4263

Yin Liu (Y)

Department of Biochemistry, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA.
Howard Hughes Medical Institute, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA.
ORCID: 0000-0002-2377-2703

Mark W Springel (MW)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-7432-7060

Annie Handler (A)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0001-6414-8627

Qiyu Zhang (Q)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-7141-4046

Brendan P Lehnert (BP)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0001-7719-5924

Chong Guo (C)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-1230-5333

Lauren L Orefice (LL)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0003-3389-7320

Amira Abdelaziz (A)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0003-1338-0463

Michelle M DeLisle (MM)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0001-8475-7411

Michael Iskols (M)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-9996-4840

Julia Rhyins (J)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-8159-0406

Soo J Kim (SJ)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

Stuart J Cattel (SJ)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

Wade Regehr (W)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-3485-8094

Christopher D Harvey (CD)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0001-9850-2268

Jan Drugowitsch (J)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0002-7846-0408

David D Ginty (DD)

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. david_ginty@hms.harvard.edu.
Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
ORCID: 0000-0001-9723-8530

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Meissner corpuscles and their spatially...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Meissner corpuscles and their spatially...
questionsmedicales.fr › Système tégumentaire › Peau › Épiderme › Meissner corpuscles and their spatially...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Meissner corpuscles and their spatially...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Mécanorécepteurs › Cellules de Merkel › Meissner corpuscles and their spatially...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Meissner corpuscles and their spatially...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Meissner corpuscles and their spatially...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Meissner corpuscles and their spatially...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Meissner corpuscles and their spatially...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Meissner corpuscles and their spatially...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Meissner corpuscles and their spatially...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Toucher › Meissner corpuscles and their spatially...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception du toucher › Meissner corpuscles and their spatially...