SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus.
B cell
BRCA1
Shld2−/− mouse
class switch recombination
shieldin
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 08 2020
05 08 2020
Historique:
received:
05
12
2019
revised:
19
05
2020
accepted:
25
05
2020
pubmed:
20
6
2020
medline:
28
4
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
The newly identified shieldin complex, composed of SHLD1, SHLD2, SHLD3, and REV7, lies downstream of 53BP1 and acts to inhibit DNA resection and promote NHEJ. Here, we show that Shld2
Identifiants
pubmed: 32558186
doi: 10.15252/embr.201949823
pmc: PMC7403657
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e49823Subventions
Organisme : CIHR
ID : FDN143343
Pays : Canada
Organisme : CIHR
ID : PJT-153307
Pays : Canada
Informations de copyright
© 2020 The Authors.
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