The importance of optimal ROIs delineation for FBPA-PET before BNCT.
BNCT
Brain stem
Cerebellum
FBPA-PET/CT
ROI
Tumour response
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
21
08
2019
revised:
27
04
2020
accepted:
04
05
2020
entrez:
21
6
2020
pubmed:
21
6
2020
medline:
11
8
2021
Statut:
ppublish
Résumé
One of the eligible criteria for patients to receive boron neutron capture therapy (BNCT) is based on the tumour-to-normal ratio (T/N) measured by FBPA-PET. However, there is no standard protocol for normal region-of-interested delineation. With comparison of contralateral cerebrum, our study revealed the consistency (p < 0.05) and high feasibility using the cerebellum as an alternative normal tissue baseline because of its homogeneous uptake. Following RECIST version 1.1, the standard-operating-procedure (SOP) for the BNCT fulfilled the expected tumour response and tumour shrinkage rate (p < 0.05). Our modified procedure can provide more precise information for BNCT within a reasonable time.
Identifiants
pubmed: 32561058
pii: S0969-8043(20)30348-1
doi: 10.1016/j.apradiso.2020.109219
pii:
doi:
Substances chimiques
Boron Compounds
0
4-borono-2-fluorophenylalanine
133921-60-5
Phenylalanine
47E5O17Y3R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109219Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflicts of interest in this study. The authors have no personal, financial or institutional interest in any drugs, materials or devices in this study.