Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
received:
24
04
2020
accepted:
27
05
2020
entrez:
21
6
2020
pubmed:
21
6
2020
medline:
9
2
2021
Statut:
ppublish
Résumé
Macrophages reside in the body cavities where they maintain serosal homeostasis and provide immune surveillance. Peritoneal macrophages are implicated in the etiology of pathologies including peritonitis, endometriosis, and metastatic cancer; thus, understanding the factors that govern their behavior is vital. Using a combination of fate mapping techniques, we have investigated the impact of sex and age on murine peritoneal macrophage differentiation, turnover, and function. We demonstrate that the sexually dimorphic replenishment of peritoneal macrophages from the bone marrow, which is high in males and very low in females, is driven by changes in the local microenvironment that arise upon sexual maturation. Population and single-cell RNA sequencing revealed marked dimorphisms in gene expression between male and female peritoneal macrophages that was, in part, explained by differences in composition of these populations. By estimating the time of residency of different subsets within the cavity and assessing development of dimorphisms with age and in monocytopenic
Identifiants
pubmed: 32561560
pii: 5/48/eabc4466
doi: 10.1126/sciimmunol.abc4466
pmc: PMC7610697
mid: EMS123171
pii:
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 203909
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206234
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100356
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L008076/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206234/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203909/Z/16/A
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N02995X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N024524/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P00265X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209220/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209220
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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