A clinically and genomically annotated nerve sheath tumor biospecimen repository.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
received:
20
12
2019
accepted:
12
05
2020
entrez:
21
6
2020
pubmed:
21
6
2020
medline:
5
11
2020
Statut:
epublish
Résumé
Nerve sheath tumors occur as a heterogeneous group of neoplasms in patients with neurofibromatosis type 1 (NF1). The malignant form represents the most common cause of death in people with NF1, and even when benign, these tumors can result in significant disfigurement, neurologic dysfunction, and a range of profound symptoms. Lack of human tissue across the peripheral nerve tumors common in NF1 has been a major limitation in the development of new therapies. To address this unmet need, we have created an annotated collection of patient tumor samples, patient-derived cell lines, and patient-derived xenografts, and carried out high-throughput genomic and transcriptomic characterization to serve as a resource for further biologic and preclinical therapeutic studies. In this work, we release genomic and transcriptomic datasets comprised of 55 tumor samples derived from 23 individuals, complete with clinical annotation. All data are publicly available through the NF Data Portal and at http://synapse.org/jhubiobank.
Identifiants
pubmed: 32561749
doi: 10.1038/s41597-020-0508-5
pii: 10.1038/s41597-020-0508-5
pmc: PMC7305302
doi:
Types de publication
Dataset
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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