The 7-Year Change in the Prevalence of Insulin Resistance, Inflammatory Biomarkers, and Their Determinants in an Urban South African Population.
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
/ blood
Cardiometabolic Risk Factors
Cross-Sectional Studies
Female
History, 21st Century
Humans
Inflammation
/ blood
Inflammation Mediators
/ blood
Insulin Resistance
Male
Metabolic Syndrome
/ blood
Middle Aged
Prevalence
Risk Factors
South Africa
/ epidemiology
Time Factors
Urban Population
/ statistics & numerical data
Young Adult
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
04
2020
revised:
29
04
2020
accepted:
12
05
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Insulin resistance (IR) and subclinical inflammation are involved in pathological pathways leading to the development of biological cardiovascular risk factors and subsequent cardiovascular events. Therefore, monitoring these processes can provide advanced information on the trajectory of cardiovascular risk profile of a population and inform prevention and control strategies. We investigated changes in IR and subclinical inflammation in a population from Cape Town, South Africa, between 2008/09 and 2014/16. In a total of 2503 ( The mean age of participants was 53.2 (2008/09) and 48.2 (2014/16), respectively. In females, IR prevalence significantly decreased between 2008/09 and 2014/2016 by all indices ( Over the 7-year period, subclinical inflammation increased and this was associated with IR and the metabolic syndrome components, both of which are strong predictors of CVDs. The decrease in IR over the year period reflects in part the much younger age in the second survey.
Sections du résumé
BACKGROUND
BACKGROUND
Insulin resistance (IR) and subclinical inflammation are involved in pathological pathways leading to the development of biological cardiovascular risk factors and subsequent cardiovascular events. Therefore, monitoring these processes can provide advanced information on the trajectory of cardiovascular risk profile of a population and inform prevention and control strategies. We investigated changes in IR and subclinical inflammation in a population from Cape Town, South Africa, between 2008/09 and 2014/16.
METHODS
METHODS
In a total of 2503 (
RESULTS
RESULTS
The mean age of participants was 53.2 (2008/09) and 48.2 (2014/16), respectively. In females, IR prevalence significantly decreased between 2008/09 and 2014/2016 by all indices (
CONCLUSIONS
CONCLUSIONS
Over the 7-year period, subclinical inflammation increased and this was associated with IR and the metabolic syndrome components, both of which are strong predictors of CVDs. The decrease in IR over the year period reflects in part the much younger age in the second survey.
Identifiants
pubmed: 32566678
doi: 10.1155/2020/3781214
pmc: PMC7261324
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Types de publication
Historical Article
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3781214Informations de copyright
Copyright © 2020 Saarah Fatoma Gadija Davids et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interests.
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