Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro.


Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
18 06 2020
Historique:
received: 15 05 2020
revised: 12 06 2020
accepted: 16 06 2020
entrez: 24 6 2020
pubmed: 24 6 2020
medline: 13 4 2021
Statut: epublish

Résumé

Plaque deposits composed of amyloid-β (Aβ) fibrils are pathological hallmarks of Alzheimer's disease (AD). Although copper ion dyshomeostasis is apparent in AD brains and copper ions are found co-deposited with Aβ peptides in patients' plaques, the molecular effects of copper ion interactions and redox-state dependence on Aβ aggregation remain elusive. By combining biophysical and theoretical approaches, we here show that Cu

Identifiants

pubmed: 32570820
pii: biom10060924
doi: 10.3390/biom10060924
pmc: PMC7355640
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Ions 0
Peptide Fragments 0
Protein Aggregates 0
Recombinant Proteins 0
amyloid beta-protein (1-42) 0
Copper 789U1901C5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Vetenskapsrådet
ID : 2016-03902
Pays : International
Organisme : Vetenskapsrådet
ID : 2019-03673
Pays : International
Organisme : Knut och Alice Wallenbergs Stiftelse
ID : Wallenberg Scholar Program
Pays : International
Organisme : Nanoscience and Nanotechnology Area of Advance, Chalmers Tekniska Högskola
ID : Excellence PhD program
Pays : International
Organisme : Nanoscience and Nanotechnology Area of Advance, Chalmers Tekniska Högskola
ID : n/a
Pays : International

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Auteurs

Nima Sasanian (N)

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

David Bernson (D)

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

Istvan Horvath (I)

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

Pernilla Wittung-Stafshede (P)

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

Elin K Esbjörner (EK)

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

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Classifications MeSH