Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL.
Adult
Aged
Aged, 80 and over
Amyloid Precursor Protein Secretases
/ antagonists & inhibitors
Antineoplastic Agents
/ administration & dosage
Apoptosis
/ drug effects
Benzazepines
/ administration & dosage
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Down-Regulation
/ drug effects
Female
Gliotoxin
/ administration & dosage
Humans
Lectins, C-Type
/ antagonists & inhibitors
Leukemia, Lymphocytic, Chronic, B-Cell
/ drug therapy
Male
Middle Aged
Nuclear Receptor Subfamily 4, Group A, Member 1
/ agonists
RNA, Messenger
/ genetics
Receptor, Notch2
/ antagonists & inhibitors
Receptor, Notch3
/ agonists
Receptors, IgE
/ antagonists & inhibitors
Regulatory Elements, Transcriptional
Signal Transduction
/ drug effects
Tumor Cells, Cultured
ATAC-seq
CD5+ B-cell homeostasis
FCER2 (CD23)
NOTCH2
NOTCH3
NR4A1
RO4929097
binary cell fate decision
chronic lymphocytic leukemia (CLL)
gliotoxin
positive/negative selection
γ-secretase inhibitors
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 06 2020
18 06 2020
Historique:
received:
28
04
2020
revised:
29
05
2020
accepted:
08
06
2020
entrez:
24
6
2020
pubmed:
24
6
2020
medline:
2
3
2021
Statut:
epublish
Résumé
NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH γ-secretase inhibitor RO4929097 in primary CLL cells with special emphasis on the individual roles of the different NOTCH receptors. Gliotoxin rapidly induced apoptosis in all CLL cases tested, whereas RO4929097 exerted a variable and delayed effect on CLL cell viability. Gliotoxin-induced apoptosis was associated with inhibition of the
Identifiants
pubmed: 32570839
pii: cells9061484
doi: 10.3390/cells9061484
pmc: PMC7348714
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzazepines
0
FCER2 protein, human
0
Lectins, C-Type
0
NOTCH2 protein, human
0
NOTCH3 protein, human
0
NR4A1 protein, human
0
Nuclear Receptor Subfamily 4, Group A, Member 1
0
RNA, Messenger
0
Receptor, Notch2
0
Receptor, Notch3
0
Receptors, IgE
0
Gliotoxin
67-99-2
Amyloid Precursor Protein Secretases
EC 3.4.-
2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide
KK8645V7LE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Leukemia. 2015 Jan;29(1):96-106
pubmed: 24781018
Blood. 2011 Jan 13;117(2):563-74
pubmed: 20940416
Blood. 2012 Jan 5;119(1):170-9
pubmed: 22086413
PLoS One. 2010 Nov 24;5(11):e15034
pubmed: 21124806
Development. 1999 Sep;126(17):3925-35
pubmed: 10433920
Nature. 2002 Apr 25;416(6883):860-5
pubmed: 11976686
Development. 2019 Feb 1;146(3):
pubmed: 30709911
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11878-83
pubmed: 12195020
Cell Death Dis. 2018 Nov 26;9(12):1160
pubmed: 30478302
Mol Cell. 2000 Oct;6(4):939-45
pubmed: 11090631
Cancer Cell. 2014 Mar 17;25(3):318-34
pubmed: 24651013
Am J Cancer Res. 2019 May 01;9(5):837-854
pubmed: 31218097
Oncotarget. 2016 Jul 5;7(27):41081-41094
pubmed: 27232759
Pharmacol Ther. 2013 Aug;139(2):95-110
pubmed: 23458608
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Nat Commun. 2016 Jun 27;7:11938
pubmed: 27346425
Biochem J. 2013 Jun 1;452(2):195-209
pubmed: 23662807
Blood. 2009 Jan 22;113(4):856-65
pubmed: 18796623
Biochem Biophys Res Commun. 2002 Mar 8;291(4):775-9
pubmed: 11866432
J Exp Med. 2014 May 5;211(5):987-1000
pubmed: 24733829
J Exp Med. 2012 Nov 19;209(12):2183-98
pubmed: 23091163
Blood. 2012 Jan 12;119(2):521-9
pubmed: 22077063
Immunol Cell Biol. 2010 Feb;88(2):117-24
pubmed: 19806164
J Exp Med. 2011 Jul 4;208(7):1389-401
pubmed: 21670202
Leukemia. 2015 Sep;29(9):1811-22
pubmed: 25917267
Leukemia. 2017 Nov;31(11):2407-2415
pubmed: 28321119
Genome Biol. 2014;15(12):550
pubmed: 25516281
Oncoimmunology. 2017 May 2;6(6):e1323155
pubmed: 28680761
Nat Rev Clin Oncol. 2019 Nov;16(11):684-701
pubmed: 31278397
Oncogene. 2020 Feb;39(6):1185-1197
pubmed: 31616059
Blood. 2009 Apr 30;113(18):4300-8
pubmed: 19190243
Chem Biol Drug Des. 2018 Mar;91(3):691-706
pubmed: 29078041
Bioinformatics. 2016 Feb 15;32(4):587-9
pubmed: 26508757
Nat Rev Drug Discov. 2014 May;13(5):357-78
pubmed: 24781550
Br J Haematol. 2013 Mar;160(5):618-29
pubmed: 23278106
Cancer Res. 2014 Aug 15;74(16):4211-6
pubmed: 25074616
Stem Cells. 2013 Jun;31(6):1181-92
pubmed: 23404789
Immunol Rev. 2019 Nov;292(1):37-60
pubmed: 31631352
Blood. 2002 May 15;99(10):3742-7
pubmed: 11986231
Front Pharmacol. 2017 Jul 07;8:319
pubmed: 28736522
Leukemia. 2013 Dec;27(12):2393-6
pubmed: 23860447
Blood. 2011 Feb 10;117(6):1781-91
pubmed: 21148333
Blood. 2002 Nov 15;100(10):3741-8
pubmed: 12393602
World J Biol Chem. 2017 Feb 26;8(1):45-56
pubmed: 28289518
Trends Immunol. 2013 Dec;34(12):592-601
pubmed: 23928062
J Biol Chem. 2015 Jun 26;290(26):16226-37
pubmed: 25957400
Front Oncol. 2014 Dec 04;4:345
pubmed: 25538890
Blood. 2014 Apr 10;123(15):2367-77
pubmed: 24553175
Blood. 2014 Apr 17;123(16):2451-9
pubmed: 24608975
Int J Cancer. 2013 Apr 15;132(8):1940-53
pubmed: 23001755
Front Oncol. 2018 Jun 27;8:229
pubmed: 29998084
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14715-6
pubmed: 21873209
Eur J Immunol. 2004 Aug;34(8):2158-67
pubmed: 15259013
EMBO J. 2006 Mar 8;25(5):1000-8
pubmed: 16498412
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
Int J Mol Med. 2020 Feb;45(2):279-297
pubmed: 31894255
Nature. 2011 Jun 05;475(7354):101-5
pubmed: 21642962
Br J Haematol. 2010 Mar;148(6):868-78
pubmed: 19995395
J Cell Physiol. 2020 May;235(5):4530-4544
pubmed: 31643078
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
J Biol Chem. 2004 Jul 16;279(29):30771-80
pubmed: 15123653
J Mol Endocrinol. 2009 Feb;42(2):131-8
pubmed: 18996961
Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2911-E2919
pubmed: 28314854
Science. 1999 Apr 30;284(5415):770-6
pubmed: 10221902
Haematologica. 2014 Jul;99(7):1138-48
pubmed: 24986876
Cancer Res. 2009 Oct 1;69(19):7672-80
pubmed: 19773430
Clin Cancer Res. 2019 Dec 15;25(24):7540-7553
pubmed: 31578228
J Cell Sci. 2013 May 15;126(Pt 10):2135-40
pubmed: 23729744
PLoS One. 2013 Apr 26;8(4):e61807
pubmed: 23637910