Glucocorticoid receptor gene (NR3C1) is hypermethylated in adult males with aggressive behaviour.
Adult males
Aggressive behaviour
DNA methylation
HPA axis
NR3C1 gene
Journal
International journal of legal medicine
ISSN: 1437-1596
Titre abrégé: Int J Legal Med
Pays: Germany
ID NLM: 9101456
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
27
03
2020
accepted:
28
05
2020
pubmed:
25
6
2020
medline:
3
9
2021
entrez:
25
6
2020
Statut:
ppublish
Résumé
Aggressive behaviour is a serious threat to the personal safety and property of others due to the potential that the assailant may hurt people, himself/herself or objects, and aggression has always been one of the focuses of research and concern. Accumulating evidence suggests that the hypothalamic-pituitary-adrenal (HPA) axis plays a major role in the development, elicitation, enhancement and genetic susceptibility of aggressive behaviour in humans and animals. GR (NR3C1) plays a crucial role in controlling HPA activity, which directly affects aggressive behaviour. Here, we investigated the methylation state of the NR3C1 gene promoter region and its role in aggressive behaviour in adult males for the first time by applying a case-control approach (N = 106 controls, N = 104 patients). Methylation of NR3C1 was measured in peripheral blood samples at exons 1
Identifiants
pubmed: 32577827
doi: 10.1007/s00414-020-02328-7
pii: 10.1007/s00414-020-02328-7
doi:
Substances chimiques
NR3C1 protein, human
0
Receptors, Glucocorticoid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-51Subventions
Organisme : National Natural Science Foundation of China
ID : 31660310 and 31860300
Organisme : the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University
ID : 2017FE467(-022)
Organisme : the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University
ID : 2018FE001(-131)
Organisme : Yunnan Provincial Young Academic and Technical Leader Reserve Talent Project
ID : 2018HB104
Organisme : the Hundred-Talent Program of Kunming Medical University
ID : 60117190447
Organisme : Science and Technology Innovation Group of Kunming Medical University
ID : CXTD201803
Organisme : the Key Laboratory of Forensic Genetics of Ministry of Public Security, Institute of Forensic Science
ID : 2018FGKFKT03
Organisme : State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
ID : 2017KF002
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