COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure.
Antibodies, Monoclonal, Humanized
/ administration & dosage
Betacoronavirus
COVID-19
Clinical Trials, Phase II as Topic
/ methods
Complement Inactivating Agents
/ administration & dosage
Coronavirus Infections
/ drug therapy
Drug Delivery Systems
/ methods
Endothelium, Vascular
/ drug effects
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ antagonists & inhibitors
Imatinib Mesylate
/ administration & dosage
Pandemics
/ prevention & control
Pneumonia, Viral
/ drug therapy
Protein-Tyrosine Kinases
/ antagonists & inhibitors
SARS-CoV-2
Signal Transduction
/ drug effects
COVID-19
Complement
Eculizumab
Endothelium
HIF-1-alpha
Imatinib
SARS-CoV
Thrombosis
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
01
06
2020
accepted:
09
06
2020
pubmed:
26
6
2020
medline:
15
7
2020
entrez:
26
6
2020
Statut:
ppublish
Résumé
COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials.
Identifiants
pubmed: 32583086
doi: 10.1007/s00277-020-04138-8
pii: 10.1007/s00277-020-04138-8
pmc: PMC7312112
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Complement Inactivating Agents
0
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Imatinib Mesylate
8A1O1M485B
eculizumab
A3ULP0F556
ARG tyrosine kinase
EC 2.7.1.-
Protein-Tyrosine Kinases
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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