DRD4 polymorphisms modulate reward positivity and P3a in a gambling task: Exploring a genetic basis for cultural learning.
Adolescent
Adult
Asian People
Cues
Culture
Decision Making
/ physiology
Electroencephalography
Event-Related Potentials, P300
/ physiology
Asia, Eastern
/ ethnology
Female
Gene-Environment Interaction
Humans
Male
Psychomotor Performance
/ physiology
Receptors, Dopamine D4
/ genetics
Reward
United States
/ ethnology
White People
Young Adult
DRD4
event-related potential
gene × culture interactions
reward processing
Journal
Psychophysiology
ISSN: 1540-5958
Titre abrégé: Psychophysiology
Pays: United States
ID NLM: 0142657
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
20
10
2019
revised:
04
05
2020
accepted:
11
05
2020
pubmed:
26
6
2020
medline:
9
10
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Prior work shows that people respond more plastically to environmental influences, including cultural influences, if they carry the 7 or 2-repeat (7/2R) allelic variant of the dopamine D4 receptor gene (DRD4). The 7/2R carriers are thus more likely to endorse the norms and values of their culture. So far, however, mechanisms underlying this moderation of cultural acquisition by DRD4 are unclear. To address this gap in knowledge, we tested the hypothesis that DRD4 modulates the processing of reward cues existing in the environment. About 72 young adults, preselected for their DRD4 status, performed a gambling task, while the electroencephalogram was recorded. Principal components of event-related potentials aligned to the Reward-Positivity (associated with bottom-up processing of reward prediction errors) and frontal-P3 (associated with top-down attention) were both significantly more positive following gains than following losses. As predicted, the gain-loss differences were significantly larger for 7/2R carriers than for noncarriers. Also, as predicted, the cultural backgrounds of the participants (East Asian vs. European American) did not moderate the effects of DRD4. Our findings suggest that the 7/2R variant of DRD4 enhances (a) the detection of reward prediction errors and (b) controlled attention that updates the context for the reward, thereby suggesting one possible mechanism underlying the DRD4 × Culture interactions.
Substances chimiques
DRD4 protein, human
0
Receptors, Dopamine D4
137750-34-6
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13623Informations de copyright
© 2020 Society for Psychophysiological Research.
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