Iron leakage owing to blood-brain barrier disruption in small vessel disease CADASIL.

Adult Aged Asymptomatic Diseases Blood-Brain Barrier / metabolism Brain / diagnostic imaging CADASIL / diagnostic imaging Case-Control Studies Caudate Nucleus / diagnostic imaging Cognition Corpus Callosum / diagnostic imaging Female Globus Pallidus / diagnostic imaging Humans Iron / metabolism Magnetic Resonance Imaging Male Mental Status and Dementia Tests Middle Aged Mutation Neuropsychological Tests Permeability Putamen / diagnostic imaging Receptor, Notch3 / genetics Temporal Lobe / diagnostic imaging

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
01 09 2020
Historique:
received: 21 08 2019
accepted: 02 03 2020
pubmed: 27 6 2020
medline: 27 10 2020
entrez: 27 6 2020
Statut: ppublish

Résumé

To assess the relationship among iron accumulation, blood-brain barrier (BBB) damage, and cognitive function in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We enrolled 21 patients with Among 21 This study showed that cerebral iron burden was associated with regional BBB permeability and cognitive dysfunction in patients with CADASIL, highlighting the potential of these imaging techniques as auxiliary biomarkers to monitor the course of small vessel disease.

Identifiants

DOI: 10.1212/WNL.0000000000010148 PMID: 32586899
pubmed: 32586899
pii: WNL.0000000000010148
doi: 10.1212/WNL.0000000000010148
doi:

Substances chimiques

NOTCH3 protein, human 0
Receptor, Notch3 0
Iron E1UOL152H7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1188-e1198

Informations de copyright

© 2020 American Academy of Neurology.

Auteurs

Yuto Uchida (Y)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.
ORCID: 0000-0002-6521-0784

Hirohito Kan (H)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.

Keita Sakurai (K)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.

Nobuyuki Arai (N)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.

Shohei Inui (S)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.
ORCID: 0000-0003-3021-4141

Susumu Kobayashi (S)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.

Daisuke Kato (D)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.

Yoshino Ueki (Y)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan.

Noriyuki Matsukawa (N)

From the Departments of Neurology and Neuroscience (Y. Uchida, D.K., N.M.) and Rehabilitation Medicine (Y. Ueki), Nagoya City University Graduate School of Medical Sciences; Departments of Neurology (Y. Uchida) and Radiology (S.K.), Toyokawa City Hospital, Aichi; Department of Radiology (H.K., N.A.), Nagoya City University Hospital; Department of Radiology (K.S.), Teikyo University School of Medicine; and Department of Radiology (S.I.), Neuroscience, School of Medicine, The University of Tokyo Graduate School of Medicine, Japan. norim@med.nagoya-cu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies asymptomatiques › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus encéphalique › Infarctus cérébral › CADASIL › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Noyau caudé › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Commissures du télencéphale › Corps calleux › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Globus pallidus › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Tests de l'état mental et de la démence › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Putamen › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Récepteur Notch3 › Iron leakage owing to blood-brain barrier...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe temporal › Iron leakage owing to blood-brain barrier...