Flagellar targeting of an arginine kinase requires a conserved lipidated protein intraflagellar transport (LIFT) pathway in

Arginine Kinase / metabolism Biological Transport Flagella / metabolism Protein Binding Protozoan Proteins / metabolism Trypanosoma brucei brucei / metabolism
Arl13 Arl3 Trypanosoma brucei Unc119 arginine kinase cilia flagellum flagellum/cilium lipidated protein intraflagellar transport (LIFT) protein myristoylation protein targeting proximity labeling small GTPase

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
07 08 2020
Historique:
received: 08 05 2020
revised: 18 06 2020
pubmed: 27 6 2020
medline: 20 2 2021
entrez: 27 6 2020
Statut: ppublish

Résumé

Both intraflagellar transport (IFT) and lipidated protein intraflagellar transport (LIFT) pathways are essential for cilia/flagella biogenesis, motility, and sensory functions. In the LIFT pathway, lipidated cargoes are transported into the cilia through the coordinated actions of cargo carrier proteins such as Unc119 or PDE6δ, as well as small GTPases Arl13b and Arl3 in the cilium. Our previous studies have revealed a single Arl13b ortholog in the evolutionarily divergent

Identifiants

DOI: 10.1074/jbc.RA120.014287 PMID: 32587088 PMC: PMC7415996
pubmed: 32587088
pii: S0021-9258(17)49222-2
doi: 10.1074/jbc.RA120.014287
pmc: PMC7415996
doi:

Substances chimiques

Protozoan Proteins 0
Arginine Kinase EC 2.7.3.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11326-11336

Informations de copyright

© 2020 Pandey et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflict of interest with the content of this article.

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Auteurs

Maneesha Pandey (M)

Department of Biological Sciences, National University of Singapore, Singapore.
ORCID: 0000-0003-1389-8668

Yameng Huang (Y)

Department of Biological Sciences, National University of Singapore, Singapore.

Teck Kwang Lim (TK)

Department of Biological Sciences, National University of Singapore, Singapore.

Qingsong Lin (Q)

Department of Biological Sciences, National University of Singapore, Singapore.

Cynthia Y He (CY)

Department of Biological Sciences, National University of Singapore, Singapore dbshyc@nus.edu.sg.
ORCID: 0000-0001-5506-2661

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Nitrogenous Group Acceptor) › Arginine kinase › Flagellar targeting of an arginine kinase...
questionsmedicales.fr › Métabolisme › Transport biologique › Flagellar targeting of an arginine kinase...
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Flagelles › Flagellar targeting of an arginine kinase...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Flagellar targeting of an arginine kinase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Flagellar targeting of an arginine kinase...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › Flagellar targeting of an arginine kinase...