Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn's Disease Patients: A Case Report and Review of the Literature.
Adrenal Cortex Hormones
/ administration & dosage
Adult
Anti-Inflammatory Agents
/ administration & dosage
Crohn Disease
/ drug therapy
Drug Administration Routes
Drug Hypersensitivity
/ etiology
Dyspnea
/ chemically induced
Female
Histamine Antagonists
/ administration & dosage
Humans
Injection Site Reaction
/ drug therapy
Middle Aged
Remission Induction
/ methods
Treatment Outcome
Ustekinumab
/ administration & dosage
Withholding Treatment
Crohn’s disease
Ustekinumab
infusion reaction
Journal
Journal of Crohn's & colitis
ISSN: 1876-4479
Titre abrégé: J Crohns Colitis
Pays: England
ID NLM: 101318676
Informations de publication
Date de publication:
13 Jan 2021
13 Jan 2021
Historique:
pubmed:
27
6
2020
medline:
14
10
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Recently, ustekinumab has been approved for the treatment of Crohn's disease and ulcerative colitis. Treatment is started with an intravenous induction dose, followed by a subcutaneous dosage. We present details of three patients with therapy-refractory Crohn's disease who experienced an immediate infusion reaction to intravenous administration of ustekinumab. In two of these patients a subsequent reaction to subcutaneous injections occurred. Clinical features and pathophysiology are discussed.
Identifiants
pubmed: 32588044
pii: 5862862
doi: 10.1093/ecco-jcc/jjaa115
pmc: PMC7805788
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Anti-Inflammatory Agents
0
Histamine Antagonists
0
Ustekinumab
FU77B4U5Z0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-164Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.
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