Altered miRNA landscape of the anterior cingulate cortex is associated with potential loss of key neuronal functions in depressed brain.
Anterior cingulate cortex
Gene enrichment
In silico analysis
Major depressive disorder
miRNA-seq
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
04
02
2020
revised:
05
05
2020
accepted:
09
06
2020
pubmed:
1
7
2020
medline:
24
9
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
MicroRNAs (miRNAs), a family of non-coding RNAs, have recently gained a considerable attention in neuropsychiatric disorders. Being a pleiotropic modulator of target gene(s), miRNA has been recognized as central to downstream gene regulatory networks. In the recent past, reports have suggested their role in changing the epigenetic landscape in brain of subjects with major depressive disorder (MDD). Anterior cingulate cortex (ACC) is a brain area implicated in several complex cognitive functions, such as impulse control, emotion, and decision-making and is associated with psychopathology associated with mood regulation. In this study, we examined whether MDD is associated with altered miRNA transcriptome in ACC and whether altered miRNA landscape is associated with modifications in specific gene network(s) at the functional level. Using next generation sequencing (NGS), it was observed that 117 miRNAs (4.61%) were significantly upregulated and 54 (2.13%) were downregulated in MDD subjects (n = 22) compared with non-psychiatric controls (n = 25). Using 24 most significantly upregulated miRNAs in the MDD group, we determined functional enrichment of target genes and found them to be associated with long-term potentiation, neurotrophin signaling, and axon guidance. Intra- and inter-cluster similarities of enriched terms based on overrepresented gene list showed neurobiological functions associated with neuronal growth and survival. Web centric parameters and ontology enrichment functions identified two major domains related to phosphatidyl signaling, GTPase signaling, neuronal migration, and neurotrophin signaling. Our findings of altered miRNA landscape along with a shift in targetome relate to previously reported morphometric changes and neuronal atrophy in ACC of MDD subjects.
Identifiants
pubmed: 32600964
pii: S0924-977X(20)30189-9
doi: 10.1016/j.euroneuro.2020.06.004
pmc: PMC7655604
mid: NIHMS1604074
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-84Subventions
Organisme : NIMH NIH HHS
ID : R01 MH107183
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100616
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH082802
Pays : United States
Organisme : NIAAA NIH HHS
ID : R28 AA012725
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101890
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118884
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. and ECNP. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Authors report no biomedical financial interests or potential conflicts of interest.
Références
Front Neuroanat. 2016 Dec 16;10:120
pubmed: 28018183
Mol Psychiatry. 2017 Jun;22(6):900-909
pubmed: 27137745
Int J Mol Sci. 2009 Jan;10(1):366-84
pubmed: 19333451
Neurotherapeutics. 2013 Oct;10(4):632-46
pubmed: 23817781
Mol Psychiatry. 2015 Jun;20(6):677-684
pubmed: 25824307
Front Genet. 2012 Jun 22;3:106
pubmed: 22737160
Development. 2011 Sep;138(17):3723-33
pubmed: 21828096
Neurosci Lett. 1995 Nov 24;200(3):151-4
pubmed: 9064599
Mol Pain. 2017 Jan-Dec;13:1744806917719847
pubmed: 28726541
Trends Cogn Sci. 2000 Jun;4(6):215-222
pubmed: 10827444
J Psychiatr Res. 2016 Nov;82:58-67
pubmed: 27468165
Am J Psychiatry. 2001 Mar;158(3):405-15
pubmed: 11229981
Annu Rev Cell Dev Biol. 2006;22:651-75
pubmed: 17029581
Arch Gen Psychiatry. 2012 Feb;69(2):139-49
pubmed: 21969419
J Toxicol Sci. 2016 Apr;41(2):273-9
pubmed: 26961612
PLoS One. 2012;7(3):e33201
pubmed: 22427989
Hum Brain Mapp. 2016 Sep;37(9):3337-52
pubmed: 27145016
Sci Rep. 2017 Jun 29;7(1):4387
pubmed: 28663595
Sci Rep. 2018 Feb 12;8(1):2861
pubmed: 29434331
Mol Psychiatry. 2017 Oct;22(10):1455-1463
pubmed: 27217146
J Neurobiol. 2001 Nov 15;49(3):245-53
pubmed: 11745662
Bipolar Disord. 2013 Aug;15(5):524-41
pubmed: 23773657
Psychiatry Res. 2012 Dec 30;200(2-3):389-94
pubmed: 22748186
Cell Adh Migr. 2010 Jul-Sep;4(3):337-41
pubmed: 20215865
CNS Spectr. 2008 Aug;13(8):663-81
pubmed: 18704022
Transl Psychiatry. 2015 Mar 03;5:e519
pubmed: 25734512
J Comp Neurol. 2008 Mar 1;507(1):1141-50
pubmed: 18157834
Neuron. 2007 Jun 21;54(6):873-88
pubmed: 17582329
Pharmacol Res Perspect. 2019 May 03;7(3):e00472
pubmed: 31065377
Cell Tissue Bank. 2008 Sep;9(3):205-16
pubmed: 18543078
Biol Psychiatry. 2009 Sep 1;66(5):407-14
pubmed: 19423079
Indian J Psychiatry. 2013 Jul;55(3):256-63
pubmed: 24082246
Am J Psychiatry. 2018 Mar 1;175(3):262-274
pubmed: 29361849
Lancet Neurol. 2012 Feb;11(2):189-200
pubmed: 22265214
Neuropsychopharmacology. 2017 Mar;42(4):864-875
pubmed: 27577603
Annu Rev Biophys. 2013;42:443-68
pubmed: 23495970
Nat Commun. 2019 Apr 3;10(1):1523
pubmed: 30944313
Neuron. 2015 Dec 2;88(5):861-877
pubmed: 26637795
Hum Brain Mapp. 2009 Nov;30(11):3719-35
pubmed: 19441021
Neuron. 2011 Jun 9;70(5):951-65
pubmed: 21658587
J Neuropsychiatry Clin Neurosci. 2011 Spring;23(2):121-5
pubmed: 21677237
Biol Psychiatry. 2009 May 1;65(9):792-800
pubmed: 19058788
Biol Psychiatry. 2002 Mar 1;51(5):377-86
pubmed: 11904132
Neuron. 2005 Sep 15;47(6):859-72
pubmed: 16157280