Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET.

Adult Aged Aged, 80 and over Biomarkers / blood Blood Gas Analysis Female Humans Inflammation / blood Male Middle Aged Oxyhemoglobins / metabolism Prognosis Pulmonary Disease, Chronic Obstructive / blood Severity of Illness Index Survival Rate

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 06 2020
Historique:
received: 04 02 2020
accepted: 27 05 2020
entrez: 1 7 2020
pubmed: 1 7 2020
medline: 16 12 2020
Statut: epublish

Résumé

We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-4) of the baseline dataset of the COSYCONET COPD cohort were used. The associations with dyspnea, exacerbation history, BODE-Index (cut-off ≤2) and all-cause mortality over 3 years of follow-up were determined by logistic and Cox regression analyses, with sex, age, BMI and pack years as covariates. Predictive values were evaluated by ROC curves. Capillary blood gases included SaO

Identifiants

DOI: 10.1038/s41598-020-67197-x PMID: 32601330 PMC: PMC7324620
pubmed: 32601330
doi: 10.1038/s41598-020-67197-x
pii: 10.1038/s41598-020-67197-x
pmc: PMC7324620
doi:

Substances chimiques

Biomarkers 0
Oxyhemoglobins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10544

Investigateurs

Stefan Andreas (S)
Jürgen Behr (J)
Burkhard Bewig (B)
Roland Buhl (R)
Ralf Ewert (R)
Beate Stubbe (B)
Joachim H Ficker (JH)
Manfred Gogol (M)
Christian Grohé (C)
Rainer Hauck (R)
Matthias Held (M)
Markus Henke (M)
Gerd Höffken (G)
Hugo A Katus (HA)
Anne-Marie Kirsten (AM)
Rembert Koczulla (R)
Klaus Kenn (K)
Juliane Kronsbein (J)
None Kropf-Sanchen
Christoph Lange (C)
Peter Zabel (P)
Michael Pfeifer (M)
Winfried J Randerath (WJ)
Werner Seeger (W)
Michael Studnicka (M)
Christian Taube (C)
Helmut Teschler (H)
Hartmut Timmermann (H)
J Christian Virchow (JC)
None Wagner
Hubert Wirtz (H)

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Auteurs

F C Trudzinski (FC)

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany. franziska.trudzinski@med.uni-heidelberg.de.

R A Jörres (RA)

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University (LMU), Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.

P Alter (P)

Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, Germany.

K Kahnert (K)

Department of Internal Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, Germany.

B Waschki (B)

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.

C Herr (C)

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany.

C Kellerer (C)

TUM School of Medicine, Institute of General Practice and Health Services Research, Technical University of Munich, Orleansstraße 47, 81667, Munich, Germany.

A Omlor (A)

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany.

C F Vogelmeier (CF)

Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, Germany.

S Fähndrich (S)

Department of Pneumology, University Hospital Freiburg, Freiburg, Germany.

H Watz (H)

Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.

T Welte (T)

Clinic for Pneumology, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.

B Jany (B)

Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital, Julius Maximilian University of Würzburg, Würzburg, Germany.

S Söhler (S)

Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, Germany.

F Biertz (F)

Institute for Biostatistics, Hannover Medical School, Hannover, Germany.

F Herth (F)

Department of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.

H-U Kauczor (HU)

Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Translational Lung Research Center Heidelberg (TLRC-H) member of the German Center of Lung Research, Heidelberg, Germany.

R Bals (R)

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests de chimie clinique › Analyse chimique du sang › Gazométrie sanguine › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Globines › Hémoglobines › Oxyhémoglobines › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Diagnostic › Pronostic › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Associations of oxygenated hemoglobin with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Associations of oxygenated hemoglobin with...