Determination of Selected Phthalates in Some Commercial Cosmetic Products by HPLC-UV.
BBP
DBP
DEHP
DEP
DMP
HPLC-UV
Phthalates
cosmetics
method validation
Journal
Combinatorial chemistry & high throughput screening
ISSN: 1875-5402
Titre abrégé: Comb Chem High Throughput Screen
Pays: United Arab Emirates
ID NLM: 9810948
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
12
2019
revised:
13
01
2020
accepted:
08
04
2020
pubmed:
1
7
2020
medline:
1
7
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Due to the serious toxicological risks and their widespread use, quantitative determination of phthalates in cosmetic products have importance for public health. The aim of this study was to develop a validated simple, rapid and reliable high-performance liquid chromatography (HPLC) method for the determination of phthalates which are; dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), di-n-butyl phthalate (DBP), di(2- ethylhexyl) phthalate (DEHP), in cosmetic products and to investigate these phthalate (PHT) levels in 48 cosmetic products marketing in Sivas, Turkey. Separation was achieved by a reverse-phase ACE-5 C18 column (4.6 x 250 mm, 5.0 μm). As the mobile phase, 5 mM KH2PO4 and acetonitrile were used gradiently at 1.5 ml min This method showed the high sensitivity value the limit of quantification (LOQ) values for which are below 0.64 μg mL Phthalate esters, which are mostly detected in the content of fragrance, cream and nail polish products and our research in general, are DEP (1852.1 μg mL
Identifiants
pubmed: 32603277
pii: CCHTS-EPUB-107790
doi: 10.2174/1386207323666200630113850
doi:
Substances chimiques
Cosmetics
0
Phthalic Acids
0
phthalic acid
6O7F7IX66E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1010-1022Informations de copyright
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