Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems.
TA systems
addiction
anti-addiction
antitoxin
cognate interactions
cross-interactions
molecular insulation
toxin
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
31
05
2020
revised:
18
06
2020
accepted:
19
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
3
3
2021
Statut:
epublish
Résumé
The diversity of Type-II toxin-antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin-antitoxin pairs of the same family of TA systems. Further, there is a redundant use of toxin folds for different cellular targets and complexation with different classes of antitoxins, increasing the apparent requirement for the insulation of interactions. The presence of Type II TA systems has remained enigmatic with respect to potential benefits imparted to the host cells. In some cases, they play clear roles in survival associated with unfavorable growth conditions. More generally, they can also serve as a "cure" against acquisition of highly similar TA systems such as those found on plasmids or invading genetic elements that frequently carry virulence and resistance genes. The latter model is predicated on the ability of these highly specific cognate antitoxin-toxin interactions to form cross-reactions between chromosomal antitoxins and invading toxins. This review summarizes advances in the Type II TA system models with an emphasis on antitoxin cross-reactivity, including with invading genetic elements and cases where toxin proteins share a common fold yet interact with different families of antitoxins.
Identifiants
pubmed: 32604745
pii: toxins12060422
doi: 10.3390/toxins12060422
pmc: PMC7354431
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Oklahoma Center for the Advancement of Science and Technology
ID : HR17-099
Pays : International
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