In vitro and in vivo study on the osseointegration of BCP-coated versus uncoated nondegradable thermoplastic polyurethane focal knee resurfacing implants.
Animals
Calcification, Physiologic
Cells, Cultured
Coated Materials, Biocompatible
/ chemistry
Fluorine Radioisotopes
Goats
Humans
Hydroxyapatites
/ chemistry
Knee
/ surgery
Knee Prosthesis
Mesenchymal Stem Cells
Osseointegration
Polyurethanes
/ chemistry
Positron Emission Tomography Computed Tomography
Prostheses and Implants
Sodium Fluoride
Surface Properties
Titanium
bone ingrowth
coatings
implant interface
polyurethanes
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
25
08
2019
revised:
18
04
2020
accepted:
03
06
2020
pubmed:
3
7
2020
medline:
9
11
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Focal knee resurfacing implants (FKRIs) are intended to treat cartilage defects in middle-aged patients. Most FKRIs are metal-based, which hampers follow-up of the joint using magnetic resonance imaging and potentially leads to damage of the opposing cartilage. The purpose of this study was to develop a nondegradable thermoplastic polyurethane (TPU) FKRI and investigate its osseointegration. Different surface roughness modifications and biphasic calcium phosphate (BCP) coating densities were first tested in vitro on TPU discs. The in vivo osseointegration of BCP-coated TPU implants was subsequently compared to uncoated TPU implants and the titanium bottom layer of metal control implants in a caprine model. Implants were implanted bilaterally in stifle joints and animals were followed for 12 weeks, after which the bone-to-implant contact area (BIC) was assessed. Additionally, 18F-sodium-fluoride (18F-NaF) positron emission tomography PET/CT-scans were obtained at 3 and 12 weeks to visualize the bone metabolism over time. The BIC was significantly higher for the BCP-coated TPU implants compared to the uncoated TPU implants (p = .03), and did not significantly differ from titanium (p = .68). Similar 18F-NaF tracer uptake patterns were observed between 3 and 12 weeks for the BCP-coated TPU and titanium implants, but not for the uncoated implants. TPU FKRIs with surface modifications could provide the answer to the drawbacks of metal FKRIs.
Identifiants
pubmed: 32614486
doi: 10.1002/jbm.b.34672
pmc: PMC7586808
doi:
Substances chimiques
Coated Materials, Biocompatible
0
Fluorine Radioisotopes
0
Hydroxyapatites
0
Polyurethanes
0
hydroxyapatite-beta tricalcium phosphate
0
Sodium Fluoride
8ZYQ1474W7
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3370-3382Informations de copyright
© 2020 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.
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