Development of a Convergent Enantioselective Synthetic Route to (-)-Myrocin G.
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
17 07 2020
17 07 2020
Historique:
pubmed:
3
7
2020
medline:
24
6
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Myrocins are a family of antiproliferative antibiotic fungal metabolites possessing a masked electrophilic cyclopropane. Preliminary chemical reactivity studies imputed the bioactivity of these natural products to a DNA cross-linking mechanism, but this hypothesis was not confirmed by studies with native DNA. We recently reported a total synthesis of (-)-myrocin G (
Identifiants
pubmed: 32615040
doi: 10.1021/acs.joc.0c00891
pmc: PMC7520802
mid: NIHMS1631311
doi:
Substances chimiques
Biological Products
0
Lactones
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8952-8989Subventions
Organisme : NCI NIH HHS
ID : F31 CA213964
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131913
Pays : United States
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