Noninvasive Fetal Electrocardiography in the Diagnosis of Long QT Syndrome: A Case Series.
Arrhythmias
Congenital long QT syndrome
Noninvasive fetal electrocardiography
Prenatal diagnosis
Journal
Fetal diagnosis and therapy
ISSN: 1421-9964
Titre abrégé: Fetal Diagn Ther
Pays: Switzerland
ID NLM: 9107463
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
01
2020
accepted:
19
04
2020
pubmed:
3
7
2020
medline:
8
7
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Early detection and monitoring for malignant arrhythmias is fundamental to prenatal care in long QT syndrome (LQTS). Recently, we studied the feasibility of isolating the fetal electrocardiogram (fECG) and measuring electrocardiographic intervals with a noninvasive fECG device using blind source separation with reference signal. Our aim was to evaluate the ability of fECG to diagnose LQTS. We identified 3 cases of clinically suspected LQTS based on fetal echocardiogram (2 had sinus bradycardia, 1 had second-degree atrioventricular block with negative maternal anti-SSA/SSB antibody titers). With institutional review board approval, these patients were prospectively enrolled for fECG acquisition. Offline post-processing generated fECG waveforms and calculated QT intervals. Case 1 and 3 had a maternal history of LQTS. Two of the three fetuses with suspected LQTS had confirmed LQTS by postnatal ECG and genetic testing. FECG was able to identify a prolonged corrected QT interval in both cases. One of these also had fetal magnetocardiography (fMCG), which yielded similar findings to the fECG. The third fetus had a normal fECG; fMCG and postnatal ECG were also normal. In 3 cases, fECG findings corroborated the diagnosis of LQTS. Noninvasive fECG may offer a novel method for fECG that is portable and more clinically accessible.
Identifiants
pubmed: 32615554
pii: 000508043
doi: 10.1159/000508043
pmc: PMC7483932
mid: NIHMS1590495
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
711-716Subventions
Organisme : NICHD NIH HHS
ID : R01 HD057965
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063174
Pays : United States
Informations de copyright
© 2020 S. Karger AG, Basel.
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