New Twists in Detecting mRNA Modification Dynamics.
2′-O-ribose methylation
Nanopore
m(5)C
m(6)A
m(6)Am
mRNA modifications
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
21
04
2020
revised:
04
06
2020
accepted:
05
06
2020
pubmed:
6
7
2020
medline:
23
9
2021
entrez:
5
7
2020
Statut:
ppublish
Résumé
Modified nucleotides in mRNA are an essential addition to the standard genetic code of four nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics examines nucleotide modifications in mRNA and their impact on gene expression. The low abundance of nucleotide modifications and technical limitations, however, have hampered systematic analysis of their occurrence and functions. Selective chemical and immunological identification of modified nucleotides has revealed global candidate topology maps for many modifications in mRNA, but further technical advances to increase confidence will be necessary. Single-molecule sequencing introduced by Oxford Nanopore now promises to overcome such limitations, and we summarize current progress with a particular focus on the bioinformatic challenges of this novel sequencing technology.
Identifiants
pubmed: 32620324
pii: S0167-7799(20)30166-9
doi: 10.1016/j.tibtech.2020.06.002
pmc: PMC7326690
pii:
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-89Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM123314
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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