NCLX prevents cell death during adrenergic activation of the brown adipose tissue.

Adipocytes, Brown / cytology Adipose Tissue, Brown / cytology Adrenergic Agents / pharmacology Animals Apoptosis / drug effects Calcium / metabolism Cells, Cultured Cold Temperature / adverse effects Cyclosporine / pharmacology Energy Metabolism / drug effects Female Intravital Microscopy Male Mice Mice, Knockout Microscopy, Fluorescence Mitochondria / drug effects Mitochondrial Membrane Transport Proteins / antagonists & inhibitors Mitochondrial Permeability Transition Pore Norepinephrine / metabolism Primary Cell Culture Signal Transduction Sodium-Calcium Exchanger / genetics Thermogenesis / drug effects

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
03 07 2020
Historique:
received: 22 08 2018
accepted: 06 05 2020
entrez: 5 7 2020
pubmed: 6 7 2020
medline: 29 8 2020
Statut: epublish

Résumé

A sharp increase in mitochondrial Ca

Identifiants

DOI: 10.1038/s41467-020-16572-3 PMID: 32620768 PMC: PMC7334226
pubmed: 32620768
doi: 10.1038/s41467-020-16572-3
pii: 10.1038/s41467-020-16572-3
pmc: PMC7334226
doi:

Substances chimiques

Adrenergic Agents 0
Mitochondrial Membrane Transport Proteins 0
Mitochondrial Permeability Transition Pore 0
Slc8b1protein, mouse 0
Sodium-Calcium Exchanger 0
Cyclosporine 83HN0GTJ6D
(melle-4)cyclosporin 96262S4I14
Calcium SY7Q814VUP
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

3347

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK099618
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK074778
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Essam A Assali (EA)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84103, Israel.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel.
ORCID: 0000-0002-7788-7047

Anthony E Jones (AE)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0003-2058-6021

Michaela Veliova (M)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Rebeca Acín-Pérez (R)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Mahmoud Taha (M)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel.

Nathanael Miller (N)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Michaël Shum (M)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Marcus F Oliveira (MF)

Institute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Guy Las (G)

Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84103, Israel.

Marc Liesa (M)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0002-5909-8570

Israel Sekler (I)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel. sekler@bgu.ac.il.

Orian S Shirihai (OS)

Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. Oshirihai@mednet.ucla.edu.
Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84103, Israel. Oshirihai@mednet.ucla.edu.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. Oshirihai@mednet.ucla.edu.
ORCID: 0000-0001-8466-3431

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Adipocytes bruns › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Eucaryotes › Animaux › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Cellules › Cellules cultivées › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Basse température › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Cyclosporines › Ciclosporine › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Techniques d'investigation › Microscopie intravitale › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Techniques d'investigation › Microscopie de fluorescence › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Pore de transition de perméabilité mitochondriale › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Antiports › Échangeur sodium-calcium › NCLX prevents cell death during adrenergic...
questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Régulation de la température corporelle › Thermogenèse › NCLX prevents cell death during adrenergic...