Aversive perception in a threat context: Separate and independent neural activation.
Affective scenes
Amygdala
Anterior insula
Threat of shock
fMRI
Journal
Biological psychology
ISSN: 1873-6246
Titre abrégé: Biol Psychol
Pays: Netherlands
ID NLM: 0375566
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
02
03
2020
revised:
22
06
2020
accepted:
26
06
2020
pubmed:
6
7
2020
medline:
6
3
2021
entrez:
5
7
2020
Statut:
ppublish
Résumé
Unpleasant, compared to neutral, scenes reliably prompt enhanced functional brain activity in the amygdala and inferotemporal cortex. Considering data from psychophysiological studies in which defensive reactivity is further enhanced when viewing unpleasant scenes under threat of shock (compared to safety), the current study investigates functional activation in the amygdala-inferotemporal circuit when unpleasant (or neutral) scenes are viewed under threat of shock or safety. In this paradigm, a cue signaling threat or safety was presented in conjunction with either an unpleasant or neutral picture. Replicating previous studies, unpleasant, compared to neutral, scenes reliably enhanced activation in the amygdala and inferotemporal cortex. Functional activity in these regions, however, did not differ whether scenes were presented in a context threatening shock exposure, compared to safety, which instead activated regions of the anterior insula and cingulate cortex. Taken together, the data support a view in which neural regions activated in different defensive situations act independently.
Identifiants
pubmed: 32621851
pii: S0301-0511(20)30086-7
doi: 10.1016/j.biopsycho.2020.107926
pmc: PMC7490760
mid: NIHMS1615980
pii:
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
107926Subventions
Organisme : NIMH NIH HHS
ID : F31 MH080551
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH072850
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE013956
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
PLoS Biol. 2015 Jun 22;13(6):e1002180
pubmed: 26098873
Nat Rev Neurosci. 2010 Nov;11(11):773-83
pubmed: 20959860
Prog Neurobiol. 1999 Oct;59(2):107-28
pubmed: 10463792
Biol Psychol. 2013 Sep;94(1):130-5
pubmed: 23727541
Psychophysiology. 2020 Jan;57(1):e13349
pubmed: 30861143
Psychophysiology. 2020 Apr;57(4):e13522
pubmed: 32011742
Neuroimage. 2005 Feb 15;24(4):1265-70
pubmed: 15670706
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
Cereb Cortex. 2013 Jan;23(1):49-60
pubmed: 22250290
J Neurosci. 2009 Nov 25;29(47):14864-8
pubmed: 19940182
Psychophysiology. 2015 Mar;52(3):325-32
pubmed: 25250656
PLoS One. 2013;8(1):e54003
pubmed: 23342060
Neuropsychopharmacology. 2019 Mar;44(4):695-702
pubmed: 30181595
J Comp Neurol. 2005 Jun 13;486(4):295-317
pubmed: 15846786
Neuroimage. 2008 Apr 15;40(3):1016-33
pubmed: 18261932
Behav Neurosci. 2003 Apr;117(2):369-80
pubmed: 12708533
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3640-8
pubmed: 23184972
Prog Brain Res. 2019;247:1-21
pubmed: 31196430
Biol Psychiatry. 2020 Mar 15;87(6):548-558
pubmed: 31547934
Transl Psychiatry. 2015 Jun 30;5:e591
pubmed: 26125154
Transl Psychiatry. 2017 Nov 30;7(12):1266
pubmed: 29213110
Soc Cogn Affect Neurosci. 2017 Sep 1;12(9):1402-1413
pubmed: 28505380
Hum Brain Mapp. 2015 Apr;36(4):1381-92
pubmed: 25504854
Neuroscience. 2014 Sep 26;277:229-38
pubmed: 25018086
J Neurophysiol. 2019 Oct 1;122(4):1530-1537
pubmed: 31166811
Behav Neurosci. 1986 Feb;100(1):11-22
pubmed: 3954873
Psychophysiology. 2018 Feb;55(2):
pubmed: 28881032
Psychophysiology. 1991 Sep;28(5):588-95
pubmed: 1758934
Biol Psychol. 2010 Jul;84(3):437-50
pubmed: 19879918
Ann N Y Acad Sci. 2003 Dec;1000:337-47
pubmed: 14766647
J Neurosci. 1996 Jun 1;16(11):3775-89
pubmed: 8642420
Brain. 1998 Jan;121 ( Pt 1):47-57
pubmed: 9549487
Neuroimage. 2011 Mar 1;55(1):389-400
pubmed: 21111828
Emotion. 2001 Sep;1(3):276-98
pubmed: 12934687
Behav Neurosci. 1991 Dec;105(6):826-42
pubmed: 1663757
Nat Neurosci. 2004 Nov;7(11):1271-8
pubmed: 15494727