Cross-infection of adenovirus among medical staff: A warning from the intensive care unit in a tertiary care teaching hospital in China.
Adenovirus Infections, Human
/ epidemiology
Adenoviruses, Human
/ classification
Adult
China
/ epidemiology
Cross Infection
/ epidemiology
Female
Hand Hygiene
Hospitals, Teaching
/ statistics & numerical data
Humans
Intensive Care Units
/ statistics & numerical data
Male
Medical Staff
/ statistics & numerical data
Middle Aged
Phylogeny
Tertiary Healthcare
/ statistics & numerical data
Young Adult
Disease outbreak
Epidemiology
HAdV-55
Human adenovirus
Medical staff
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
27
05
2020
revised:
19
06
2020
accepted:
20
06
2020
pubmed:
6
7
2020
medline:
11
11
2020
entrez:
6
7
2020
Statut:
ppublish
Résumé
In 2019, a small HAdV55-associated outbreak of adenovirus infection occurred among the intensive care unit (ICU) staff in Xiangya Hospital of Central South University in Hunan Province, China, during the treatment of a patient. To investigate the characteristics of a nosocomial adenovirus outbreak in an ICU. We evaluated all the patients treated and the medical staff working in the ICU from August 1 to September 4, 2019. We further performed an epidemiological and molecular analysis for this outbreak from patient to healthcare workers and between healthcare workers. After the outbreak, we adopted exposure prevention and droplet prevention measures based on standard precautions. Between August 1 and August 27, 2019, 27 cases of human adenovirus cross-infection were reported in our institution. Among the cases, eleven were doctors (41%), eleven were nurses (41%), three were respiratory therapists (11%), and two were caregivers (7%). The attack rate was 28.4%, and the fatality rate was 0. The results showed that contact with the index case, lack of hand hygiene or gloving adherence were risk factors for infection after adenovirus exposure. After taking specific precautions, no new cases of infection have appeared since August 27. Our results show that HAdV55 in a single patient had strong transmission potential in an intensive care unit with adequate facilities and standardized operation. We provide convincing evidence indicating that attention could be highlighted on the role of standard and specific precautions for controlling the spread of adenovirus in ICUs.
Identifiants
pubmed: 32623086
pii: S1201-9712(20)30538-5
doi: 10.1016/j.ijid.2020.06.103
pmc: PMC7330577
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
390-397Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
Emerg Infect Dis. 2018 Nov;24(11):2117-2119
pubmed: 30334721
Euro Surveill. 2014 Oct 02;19(39):
pubmed: 25306980
N Engl J Med. 2003 Mar 27;348(13):1256-66
pubmed: 12660390
Open Forum Infect Dis. 2019 Jan 11;6(2):ofz017
pubmed: 30800698
Proc Soc Exp Biol Med. 1953 Dec;84(3):570-3
pubmed: 13134217
Curr Opin Pulm Med. 2019 May;25(3):220-224
pubmed: 30730312
Biomedicines. 2019 Aug 19;7(3):
pubmed: 31430920
Int J Infect Dis. 2014 Nov;28:117-22
pubmed: 25236387
Lancet. 2011 Apr 9;377(9773):1264-75
pubmed: 21435708
Clin Microbiol Rev. 2008 Oct;21(4):704-15
pubmed: 18854488
PLoS One. 2011 Apr 29;6(4):e19496
pubmed: 21559339
N Engl J Med. 2015 Jul 30;373(5):415-27
pubmed: 26172429
Semin Respir Crit Care Med. 2011 Aug;32(4):494-511
pubmed: 21858752
Bull World Health Organ. 1953;8(5-6):613-31
pubmed: 13094497
J Clin Virol. 2018 Dec;109:35-40
pubmed: 30399502
Eur J Clin Microbiol Infect Dis. 2008 Feb;27(2):153-8
pubmed: 18030505
Influenza Other Respir Viruses. 2014 May;8(3):302-8
pubmed: 24467816
Clin Infect Dis. 2004 May 15;38(10):1420-7
pubmed: 15156481
Clin Microbiol Rev. 2014 Jul;27(3):441-62
pubmed: 24982316
Emerg Infect Dis. 2016 Jun;22(6):1044-51
pubmed: 27191834
PLoS One. 2016 Mar 11;11(3):e0151199
pubmed: 26967644
Virol J. 2018 Oct 3;15(1):153
pubmed: 30285778
PLoS One. 2017 Jan 23;12(1):e0170592
pubmed: 28114362
J Infect Dis. 2020 Feb 18;221(5):697-700
pubmed: 30783668
BMC Infect Dis. 2018 Dec 7;18(1):634
pubmed: 30526511
Chest. 2014 Jan;145(1):79-86
pubmed: 24551881
Am J Infect Control. 2016 May 1;44(5):602-4
pubmed: 26804304
MMWR Morb Mortal Wkly Rep. 2013 Aug 16;62(32):637-41
pubmed: 23945769
Epidemiol Infect. 2020 Jan 03;147:e328
pubmed: 31896387
Semin Respir Crit Care Med. 2016 Aug;37(4):586-602
pubmed: 27486739
MMWR Morb Mortal Wkly Rep. 2017 Oct 06;66(39):1039-1042
pubmed: 28981484
Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):793-800
pubmed: 30693422
Infect Dis (Lond). 2016;48(6):432-5
pubmed: 27030915
J Intensive Care Med. 2016 Aug;31(7):427-41
pubmed: 25990273