Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia.

Adult Aged Aged, 80 and over Betacoronavirus / immunology Biomarkers / metabolism CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology COVID-19 Cellular Senescence Coronavirus Infections / blood Cytokine Release Syndrome Cytokines / immunology Female Humans Immunologic Memory Italy / epidemiology Lymphocyte Activation Lymphocyte Count Male Middle Aged Pandemics Pneumonia, Viral / blood SARS-CoV-2 T-Lymphocyte Subsets / immunology Th17 Cells / immunology

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
06 07 2020

Historique:

received: 24 03 2020

accepted: 23 06 2020

entrez: 8 7 2020

pubmed: 8 7 2020

medline: 18 7 2020

Statut: epublish

Résumé

The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1

Identifiants

DOI: 10.1038/s41467-020-17292-4 PMID: 32632085 PMC: PMC7338513

pubmed: 32632085

doi: 10.1038/s41467-020-17292-4

pii: 10.1038/s41467-020-17292-4

pmc: PMC7338513

doi:

Substances chimiques

Biomarkers 0

Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

3434

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