Constituents from Solidago virgaurea var. gigantea and their inhibitory effect on lipid accumulation.
3T3-L1 Cells
Adipocytes
/ drug effects
Animals
Anti-Obesity Agents
/ isolation & purification
Chlorogenic Acid
/ analogs & derivatives
Cinnamates
/ isolation & purification
Kaempferols
Lipid Metabolism
/ drug effects
Mice
Molecular Structure
Phytochemicals
/ isolation & purification
Plant Components, Aerial
/ chemistry
Quinic Acid
/ analogs & derivatives
Republic of Korea
Solidago
/ chemistry
(1R,2S,3S,5R,7S)-methyl 7-((cinnamoyloxy)methyl)-2,3-dihydroxy-6,8-dioxabicyclo[3.2.1]octane-5-carboxylate
Anti-adipogenic activity
Lipid accumulation
Solidago viraurea var. gigantean (Nakai)
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
11
05
2020
revised:
23
06
2020
accepted:
29
06
2020
pubmed:
8
7
2020
medline:
16
3
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
In this study, the anti-adipogenic activities of compounds isolated from Solidago viraurea var. gigantea (SG) extracts were investigated using Oil Red O staining in the 3T3-L1 cell line. Four known compounds including 3,5-di-O-caffeoylquinic acid (5), protocatechuic acid (6), chlorogenic acid (7), and kaempferol-3-O-rutinoside (8), and four undescribed compounds including (1R,2S,3S,5R,7S)-methyl 7-((cinnamoyloxy)methyl)-2,3-dihydroxy-6,8-dioxabicyclo[3.2.1]octane-5-carboxylate (1), (1R,2S,3S,5R,7S)-methyl 2,3-dihydroxy-7-((((Z)-3-phenylacryloyl)oxy)methyl)-6,8-dioxabicyclo[3.2.1]octane-5-carboxylate (2), (1R,2S,3S,5R,7S)-2,3-dihydroxy-7-((((Z)-3-phenylacryloyl)oxy)methyl)-6,8-dioxabicyclo[3.2.1]octane-5-carboxylic acid (3), and (1R,2S,3S,5R,7S)-7-((cinnamoyloxy)methyl)-2,3-dihydroxy-6,8-dioxabicyclo[3.2.1]octane-5-carboxylic acid (4) were isolated from S. viraurea var. gigantea. The structures of the compounds were first identified by comparing their
Identifiants
pubmed: 32634454
pii: S0367-326X(20)30265-3
doi: 10.1016/j.fitote.2020.104683
pii:
doi:
Substances chimiques
Anti-Obesity Agents
0
Cinnamates
0
Kaempferols
0
Phytochemicals
0
Quinic Acid
058C04BGYI
cinnamic acid
140-10-3
Chlorogenic Acid
318ADP12RI
kaempferol-3-O-rutinoside
4056D20K3H
5'-O-caffeoylquinic acid
O4601UER1Z
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104683Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interest.