Determination of the phylogenetic origins of the Árpád Dynasty based on Y chromosome sequencing of Béla the Third.
Journal
European journal of human genetics : EJHG
ISSN: 1476-5438
Titre abrégé: Eur J Hum Genet
Pays: England
ID NLM: 9302235
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
05
11
2019
accepted:
25
06
2020
revised:
16
06
2020
pubmed:
9
7
2020
medline:
17
8
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
We set out to identify the origins of the Árpád Dynasty based on genome sequencing of DNA derived from the skeletal remains of Hungarian King Béla III (1172-1196) and eight additional individuals (six males, two females) originally interred at the Royal Basilica of Székesfehérvár. Y-chromosome analysis established that two individuals, Béla III and HU52 assign to haplogroups R-Z2125 whose distribution centres near South Central Asia with subsidiary expansions in the regions of modern Iran, the Volga Ural region and the Caucasus. Out of a cohort of 4340 individuals from these geographic areas, we acquired whole-genome data from 208 individuals derived for the R-Z2123 haplogroup. From these data we have established that the closest living kin of the Árpád Dynasty are R-SUR51 derived modern day Bashkirs predominantly from the Burzyansky and Abzelilovsky districts of Bashkortostan in the Russian Federation. Our analysis also reveals the existence of SNPs defining a novel Árpád Dynasty specific haplogroup R-ARP. Framed within the context of a high resolution R-Z2123 phylogeny, the ancestry of the first Hungarian royal dynasty traces to the region centering near Northern Afghanistan about 4500 years ago and identifies the Bashkirs as their closest kin, with a separation date between the two populations at the beginning of the first millennium CE.
Identifiants
pubmed: 32636469
doi: 10.1038/s41431-020-0683-z
pii: 10.1038/s41431-020-0683-z
pmc: PMC7809292
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
164-172Commentaires et corrections
Type : ErratumIn
Références
Hóman B. Geschichte des Ungarischen Mittelalters. Berlin: Walter de Gruyter; 1940–43.
Neparaczki E, Juhasz Z, Pamjav H, Feher T, Csanyi B, Zink A, et al. Genetic structure of the early Hungarian conquerors inferred from mtDNA haplotypes and Y-chromosome haplogroups in a small cemetery. Mol Genet Genom. 2017;292:201–14.
doi: 10.1007/s00438-016-1267-z
Neparaczki E, Kocsy K, Toth GE, Maroti Z, Kalmar T, Bihari P, et al. Revising mtDNA haplotypes of the ancient Hungarian conquerors with next generation sequencing. PLoS ONE 2017;12:e0174886.
doi: 10.1371/journal.pone.0174886
Tomory G, Csanyi B, Bogacsi-Szabo E, Kalmar T, Czibula A, Csosz A, et al. Comparison of maternal lineage and biogeographic analyses of ancient and modern Hungarian populations. Am J Phys Anthropol. 2007;134:354–68.
doi: 10.1002/ajpa.20677
Csosz A, Szecsenyi-Nagy A, Csakyova V, Lango P, Bodis V, Kohler K, et al. Maternal genetic ancestry and legacy of 10(th) century AD Hungarians. Sci Rep. 2016;6:33446.
doi: 10.1038/srep33446
Neparaczki E, Maroti Z, Kalmar T, Maar K, Nagy I, Latinovics D, et al. Y-chromosome haplogroups from Hun, Avar and conquering Hungarian period nomadic people of the Carpathian Basin. Sci Rep. 2019;9:16569.
doi: 10.1038/s41598-019-53105-5
Olasz J, Seidenberg V, Hummel S, Szentirmay Z, Szabados G, Melegh B, et al. DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár. Archaeol Anthropol Sci. 2019;11:1345–57.
doi: 10.1007/s12520-018-0609-7
Szentpétery I. Scriptores Rerum Hungaricarum. Budapest: Academia Litteraria Hungarica; 1937–38.
Engel P. Temetkezések a középkori székesfehérvári bazilikában [Burials in the medieval Basilica of Székesfehérvár]. Századok. 1987;121:613–37.
Érdy J III. Béla király és nejének Székes-Fehérvárott talált síremlékei [The tombs of king Béla III and his spouse found in Székes-Fehérvár]. Pest: Emich G; 1853.
Éry K (ed). A székesfehérvári királyi bazilika embertani leletei 1848-2002. Budapest: Balassi Kiadó; 2008.
Poznik GD, Henn BM, Yee MC, Sliwerska E, Euskirchen GM, Lin AA, et al. Sequencing Y chromosomes resolves discrepancy in time to common ancestor of males versus females. Science 2013;341:562–5.
doi: 10.1126/science.1237619
Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A, Wilson Sayres MA, et al. Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nat Genet. 2016;48:593–9.
doi: 10.1038/ng.3559
Karmin M, Saag L, Vicente M, Wilson Sayres MA, Jarve M, Talas UG, et al. A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Res. 2015;25:459–66.
doi: 10.1101/gr.186684.114
International Society of Genetic Genealogy. Y-DNA Haplogroup Tree 2019, Version:14.22, Date: 25 January 2019, http://www.isogg.org/tree/
Behar DM, Saag L, Karmin M, Gover MG, Wexler JD, Sanchez LF, et al. The genetic variation in the R1a clade among the Ashkenazi Levites’ Y chromosome. Sci Rep. 2017;7:14969.
doi: 10.1038/s41598-017-14761-7
Inc. I. Basespace application. www.illumina.com/BaseSpaceApps .
Bioinformatics B. Trim Galore. http://www.bioinformatics.babraham.ac.uk/projects/trim_galore/
Miller NA, Farrow EG, Gibson M, Willig LK, Twist G, Yoo B, et al. A 26-hour system of highly sensitive whole genome sequencing for emergency management of genetic diseases. Genome Med. 2015;7:100.
doi: 10.1186/s13073-015-0221-8
Robinson JT, Thorvaldsdottir H, Winckler W, Guttman M, Lander ES, Getz G, et al. Integrative genomics viewer. Nat Biotechnol. 2011;29:24–6.
doi: 10.1038/nbt.1754
Jonsson H, Ginolhac A, Schubert M, Johnson PL, Orlando L. mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Bioinformatics 2013;29:1682–4.
doi: 10.1093/bioinformatics/btt193
Skoglund PSJ, Götherström A, Jakobssonac M. Accurate sex identification of ancient human remains using DNA shotgun sequencing. J Archaeological Sci. 2013;40:4477–82.
doi: 10.1016/j.jas.2013.07.004
Renaud G, Slon V, Duggan AT, Kelso J. Schmutzi: estimation of contamination and endogenous mitochondrial consensus calling for ancient DNA. Genome Biol. 2015;16:224.
doi: 10.1186/s13059-015-0776-0
Rasmussen M, Guo X, Wang Y, Lohmueller KE, Rasmussen S, Albrechtsen A, et al. An Aboriginal Australian genome reveals separate human dispersals into Asia. Science 2011;334:94–8.
doi: 10.1126/science.1211177
Weissensteiner H, Pacher D, Kloss-Brandstatter A, Forer L, Specht G, Bandelt HJ, et al. HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing. Nucleic Acids Res. 2016;44(W1):W58–63.
doi: 10.1093/nar/gkw233
Ralf A, Gonzalez DM, Zhong K, Kayser M. Yleaf: software for human Y-Chromosomal Haplogroup inference from next-generation sequencing data. Mol Biol Evol. 2018;35:1820.
doi: 10.1093/molbev/msy080
Y-DNA Haplogroup Tree 2019: International Society of Genetic Genealogy; 2020. http://www.isogg.org/tree .
Y-chromosome DNA haplotree: Family Tree DNA Ltd. https://www.familytreedna.com/public/y-dna-haplotree .
Au CH, Ho DN, Kwong A, Chan TL, Ma ESK. BAMClipper: removing primers from alignments to minimize false-negative mutations in amplicon next-generation sequencing. Sci Rep. 2017;7:1567.
doi: 10.1038/s41598-017-01703-6
Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, et al. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol. 2011;7:539.
doi: 10.1038/msb.2011.75
FigTree v1.4.4. http://tree.bio.ed.ac.uk/software/figtree/ .
Cruciani F, La Fratta R, Trombetta B, Santolamazza P, Sellitto D, Colomb EB, et al. Tracing past human male movements in northern/eastern Africa and western Eurasia: new clues from Y-chromosomal haplogroups E-M78 and J-M12. Mol Biol Evol. 2007;24:1300–11.
doi: 10.1093/molbev/msm049
Balanovsky O, Dibirova K, Dybo A, Mudrak O, Frolova S, Pocheshkhova E, et al. Parallel evolution of genes and languages in the Caucasus region. Mol Biol Evol. 2011;28:2905–20.
doi: 10.1093/molbev/msr126
Myres NM, Rootsi S, Lin AA, Jarve M, King RJ, Kutuev I, et al. A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe. Eur J Hum Genet. 2011;19:95–101.
doi: 10.1038/ejhg.2010.146
Underhill PA, Poznik GD, Rootsi S, Jarve M, Lin AA, Wang J, et al. The phylogenetic and geographic structure of Y-chromosome haplogroup R1a. Eur J Hum Genet. 2015;23:124–31.
doi: 10.1038/ejhg.2014.50
Rootsi S, Behar DM, Jarve M, Lin AA, Myres NM, Passarelli B, et al. Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites. Nat Commun. 2013;4:2928.
doi: 10.1038/ncomms3928
Muratov. The genus of Shagali Shakman, the clan of Olobure and the descendants of Inas (Kipchak Khan) according to Big-Y. Bulletin of the EI Project ‘Suyun’. 2014;1:7–29.
Di Cristofaro J, Pennarun E, Mazieres S, Myres NM, Lin AA, Temori SA, et al. Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. PLoS ONE 2013;8:e76748.
doi: 10.1371/journal.pone.0076748
Zgonjanin D, Alghafri R, Antov M, Stojiljkovic G, Petkovic S, Vukovic R, et al. Genetic characterization of 27 Y-STR loci with the Yfiler((R)) Plus kit in the population of Serbia. Forensic Sci Int Genet. 2017;31:e48–9.
doi: 10.1016/j.fsigen.2017.07.013
Neparaczki E, Maroti Z, Kalmar T, Kocsy K, Maar K, Bihari P, et al. Mitogenomic data indicate admixture components of Central-Inner Asian and Srubnaya origin in the conquering Hungarians. PLoS ONE 2018;13:e0205920.
doi: 10.1371/journal.pone.0205920
Post H, Nemeth E, Klima L, Flores R, Feher T, Turk A, et al. Y-chromosomal connection between Hungarians and geographically distant populations of the Ural Mountain region and West Siberia. Sci Rep. 2019;9:7786.
doi: 10.1038/s41598-019-44272-6
Amorim CEG, Vai S, Posth C, Modi A, Koncz I, Hakenbeck S, et al. Understanding 6th-century barbarian social organization and migration through paleogenomics. Nat Commun. 2018;9:3547.
doi: 10.1038/s41467-018-06024-4
Team QD. QGIS Geographic Information System; Open Source Geospatial Foundation Project. 2015. http://www.qgis.org .