In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana.

Alleles Botswana / epidemiology Computer Simulation Epitopes, T-Lymphocyte / immunology Genes, MHC Class II / immunology HLA Antigens / immunology Hepatitis B / immunology Hepatitis B Surface Antigens / immunology Hepatitis B virus / immunology Humans Leukocytes / immunology T-Lymphocytes / immunology
Africa Botswana HLA class II alleles T-cell epitopes candidate multi-epitope vaccines (MEV) escape mutation hepatitis B virus (HBV) immunoinformatics in silico

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
06 07 2020
Historique:
received: 12 06 2020
accepted: 03 07 2020
entrez: 10 7 2020
pubmed: 10 7 2020
medline: 23 2 2021
Statut: epublish

Résumé

Hepatitis B virus (HBV) is the primary cause of liver-related malignancies worldwide, and there is no effective cure for chronic HBV infection (CHB) currently. Strong immunological responses induced by T cells are associated with HBV clearance during acute infection; however, the repertoire of epitopes (

Identifiants

DOI: 10.3390/v12070731 PMID: 32640609 PMC: PMC7412261
pubmed: 32640609
pii: v12070731
doi: 10.3390/v12070731
pmc: PMC7412261
pii:
doi:

Substances chimiques

Epitopes, T-Lymphocyte 0
HLA Antigens 0
Hepatitis B Surface Antigens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Wonderful Tatenda Choga (WT)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0001-7606-0569

Motswedi Anderson (M)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
ORCID: 0000-0001-9974-9684

Edward Zumbika (E)

Department of Applied Biology and Biochemistry, Faculty of Applied Sciences, National University of Science and Technology, Bulawayo 0000, Zimbabwe.

Bonolo B Phinius (BB)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Tshepiso Mbangiwa (T)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.

Lynnette N Bhebhe (LN)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Kabo Baruti (K)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone 0000, Botswana.

Peter Opiyo Kimathi (PO)

Centre for Proteomic and Genomic Research, Cape Town 7925, South Africa.

Kaelo K Seatla (KK)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Gaborone 0000, Botswana.
ORCID: 0000-0002-2190-2842

Rosemary M Musonda (RM)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Trevor Graham Bell (TG)

P.O. Box 497, Wits, Johannesburg 2050, South Africa.
ORCID: 0000-0003-2630-7513

Sikhulile Moyo (S)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0003-3821-4592

Jason T Blackard (JT)

Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
ORCID: 0000-0003-2876-3811

Simani Gaseitsiwe (S)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique australe › Botswana › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Gènes MHC de classe II › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Hépatite › Hépatites virales humaines › Hépatite B › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes d'hépatite virale › Antigènes de l'hépatite virale B › Antigènes de surface du virus de l'hépatite B › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › In Silico Prediction of Human Leukocytes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › In Silico Prediction of Human Leukocytes...