Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
07
04
2020
accepted:
09
06
2020
pubmed:
10
7
2020
medline:
23
3
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
Mucosal surfaces such as fish gills interface between the organism and the external environment and as such are major sites of foreign Ag encounter. In the gills, the balance between inflammatory responses to waterborne pathogens and regulatory responses toward commensal microbes is critical for effective barrier function and overall fish health. In mammals, IL-4 and IL-13 in concert with IL-10 are essential for balancing immune responses to pathogens and suppressing inflammation. Although considerable progress has been made in the field of fish immunology in recent years, whether the fish counterparts of these key mammalian cytokines perform similar roles is still an open question. In this study, we have generated IL-4/13A and IL-4/13B mutant zebrafish (
Identifiants
pubmed: 32641385
pii: jimmunol.2000372
doi: 10.4049/jimmunol.2000372
pmc: PMC7416321
doi:
Substances chimiques
Fish Proteins
0
Interleukin-13
0
Interleukin-10
130068-27-8
Interleukin-4
207137-56-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
994-1008Subventions
Organisme : Wellcome Trust
ID : 102171/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106898/A/15/Z
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/M001512/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K01207X/2
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L007401/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109057/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors.
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