Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury.
Schwann cell
autophagy
calcineurin
myelin
nerve injury
nerve regeneration
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
05 08 2020
05 08 2020
Historique:
received:
22
04
2020
revised:
09
06
2020
accepted:
20
06
2020
pubmed:
10
7
2020
medline:
5
1
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
In the PNS, myelination occurs postnatally when Schwann cells (SCs) contact axons. Axonal factors, such as Neuregulin-1 Type III, trigger promyelinating signals that upregulate myelin genes. Neuregulin-1 Type III has been proposed to activate calcineurin signaling in immature SCs to initiate differentiation and myelination. However, little is known about the role of calcineurin in promyelinating SCs after birth. By creating a SC conditional KO of calcineurin B (CnB
Identifiants
pubmed: 32641402
pii: JNEUROSCI.0951-20.2020
doi: 10.1523/JNEUROSCI.0951-20.2020
pmc: PMC7406276
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Tcfeb protein, mouse
0
Calcineurin
EC 3.1.3.16
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6165-6176Subventions
Organisme : NINDS NIH HHS
ID : R01 NS111715
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100464
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS096104
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS045630
Pays : United States
Organisme : NINDS NIH HHS
ID : F30 NS105405
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS055256
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
Références
Glia. 2019 Apr;67(4):571-581
pubmed: 30378179
Eur J Neurosci. 1999 May;11(5):1577-86
pubmed: 10215910
J Neurosci. 2011 Mar 2;31(9):3225-33
pubmed: 21368034
J Neurosci. 2016 Apr 20;36(16):4506-21
pubmed: 27098694
J Neurosci Res. 2013 Jan;91(1):105-15
pubmed: 23073893
Autophagy. 2012 Jun;8(6):903-14
pubmed: 22576015
Science. 2009 Jan 30;323(5914):651-4
pubmed: 19179536
PLoS One. 2014 Aug 21;9(8):e105601
pubmed: 25144298
J Cell Biol. 2002 Jan 7;156(1):199-209
pubmed: 11777940
J Neuropathol Exp Neurol. 1981 Mar;40(2):134-54
pubmed: 7463099
J Immunol. 2008 Mar 1;180(5):3183-9
pubmed: 18292542
J Neurosurg. 1993 Jan;78(1):90-100
pubmed: 8416248
Neuron. 2012 Feb 23;73(4):729-42
pubmed: 22365547
Neuron. 2000 Oct;28(1):41-51
pubmed: 11086982
J Neurosci. 2004 Jul 28;24(30):6724-32
pubmed: 15282275
Neuron. 1994 Mar;12(3):509-27
pubmed: 8155318
Ann N Y Acad Sci. 2016 May;1371(1):3-14
pubmed: 27299292
J Mol Neurosci. 2016 Apr;58(4):416-23
pubmed: 26738732
Anat Cell Biol. 2011 Mar;44(1):41-9
pubmed: 21519548
Neuron. 2011 Jan 13;69(1):91-105
pubmed: 21220101
Science. 2009 Jul 24;325(5939):473-7
pubmed: 19556463
Sci Signal. 2012 Jun 12;5(228):ra42
pubmed: 22692423
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8072-E8080
pubmed: 28874532
Glia. 1996 Aug;17(4):294-306
pubmed: 8856326
J Neurosci. 2016 Nov 2;36(44):11350-11361
pubmed: 27807175
J Cell Biol. 2008 May 19;181(4):625-37
pubmed: 18490512
Nat Cell Biol. 2013 Jun;15(6):647-58
pubmed: 23604321
Nat Neurosci. 2013 Jan;16(1):48-54
pubmed: 23222914
J Neurosci. 2010 Jun 30;30(26):8953-64
pubmed: 20592216
Nat Commun. 2017 Dec 22;8(1):2270
pubmed: 29273768
Exp Cell Res. 1976 Jul;100(2):276-80
pubmed: 939253
EMBO J. 2012 Mar 7;31(5):1095-108
pubmed: 22343943
Immunity. 2004 Mar;20(3):255-66
pubmed: 15030770
Microsc Res Tech. 2002 Jun 15;57(6):541-7
pubmed: 12112437
Brain Res. 2010 Jul 23;1345:59-72
pubmed: 20510892
Neuron. 2005 Sep 1;47(5):681-94
pubmed: 16129398
F1000 Biol Rep. 2010 Mar 15;2:
pubmed: 20948814
Genes Dev. 2014 Feb 1;28(3):290-303
pubmed: 24493648
Exp Neurol. 2003 Sep;183(1):220-31
pubmed: 12957505
Neuron. 2012 Aug 23;75(4):633-47
pubmed: 22920255
Neuron. 1999 Jun;23(2):273-83
pubmed: 10399934
J Neurol Sci. 1988 Jan;83(1):37-53
pubmed: 3126271
Nat Cell Biol. 2015 Mar;17(3):288-99
pubmed: 25720963
J Neurosci. 1995 Nov;15(11):7509-16
pubmed: 7472502
EMBO J. 2016 Mar 1;35(5):479-95
pubmed: 26813791
J Neurosci. 2018 May 16;38(20):4811-4828
pubmed: 29695414
Curr Biol. 1998 Dec 3;8(24):1323-6
pubmed: 9843687
Glia. 2016 May;64(5):730-42
pubmed: 26712109
Mol Cell Neurosci. 2007 May;35(1):153-60
pubmed: 17383197
Autophagy. 2011 Nov;7(11):1379-81
pubmed: 21785263
J Cell Biol. 2015 Jul 6;210(1):153-68
pubmed: 26150392
Development. 2004 Nov;131(22):5599-612
pubmed: 15496445
Neuron. 1994 Sep;13(3):757-67
pubmed: 7522484
Methods Mol Biol. 2015;1219:187-97
pubmed: 25308270
Restor Neurol Neurosci. 1994 Jan 1;6(4):287-96
pubmed: 21551759
Autophagy. 2016 Aug 2;12(8):1372-89
pubmed: 27172265
Mol Cell. 2018 Nov 1;72(3):457-468.e5
pubmed: 30344099
Ann N Y Acad Sci. 1999 Oct;883(1):116-123
pubmed: 29086916
Mol Cell Neurosci. 1996 Feb;7(2):89-101
pubmed: 8731478