SARS-CoV-2 is transmitted via contact and via the air between ferrets.
Animals
Antibodies, Viral
/ blood
Betacoronavirus
/ genetics
COVID-19
Coronavirus Infections
/ transmission
Disease Models, Animal
Ferrets
Genome, Viral
/ genetics
Humans
Pandemics
Pneumonia, Viral
/ transmission
Rectum
/ virology
Respiratory System
/ virology
SARS-CoV-2
Sequence Analysis, RNA
Virus Shedding
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
15
04
2020
accepted:
25
06
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
18
7
2020
Statut:
epublish
Résumé
SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days and 3 to 7 days after exposure respectively. The pattern of virus shedding in the direct contact and indirect recipient ferrets is similar to that of the inoculated ferrets and infectious virus is isolated from all positive animals, showing that ferrets are productively infected via either route. This study provides experimental evidence of robust transmission of SARS-CoV-2 via the air, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings.
Identifiants
pubmed: 32641684
doi: 10.1038/s41467-020-17367-2
pii: 10.1038/s41467-020-17367-2
pmc: PMC7343828
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3496Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 731014
Pays : International
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