Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis.
Animals
Calcium Oxalate
/ chemistry
Coculture Techniques
Crystallization
Disease Models, Animal
Epithelial Cells
Humans
Interferon Regulatory Factor-1
/ genetics
Isothiocyanates
/ pharmacology
Kidney Tubules
/ drug effects
Macrophage Activation
/ drug effects
Macrophages
/ drug effects
Mice
MicroRNAs
/ genetics
NF-E2-Related Factor 2
/ agonists
Nephritis
/ drug therapy
Nephrocalcinosis
/ complications
Primary Cell Culture
Signal Transduction
/ drug effects
Sulfoxides
/ pharmacology
Toll-Like Receptor 4
/ genetics
Transcriptional Activation
/ immunology
IRF1
Macrophage
Nrf2
Sulforaphane
TLR4
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
01
2020
accepted:
06
05
2020
entrez:
10
7
2020
pubmed:
10
7
2020
medline:
4
5
2021
Statut:
epublish
Résumé
Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cells (TECs) injury and inflammation, which involve Toll-like receptor 4 (TLR4)/interferon regulatory factor 1 (IRF1) signaling. Additionally, infiltrating macrophages (Mϕs) might influence intrarenal CaOx crystals and CaOx-induced renal injury. Although the roles of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating inflammation and macrophage polarization are well characterized, its potential mechanisms in regulating CaOx nephrocalcinosis remain undefined.
Identifiants
pubmed: 32641994
doi: 10.7150/thno.44054
pii: thnov10p7319
pmc: PMC7330860
doi:
Substances chimiques
Interferon Regulatory Factor-1
0
Irf1 protein, mouse
0
Isothiocyanates
0
MicroRNAs
0
Mirn93 microRNA, mouse
0
NF-E2-Related Factor 2
0
Nfe2l2 protein, mouse
0
Sulfoxides
0
Tlr4 protein, mouse
0
Toll-Like Receptor 4
0
Calcium Oxalate
2612HC57YE
sulforaphane
GA49J4310U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7319-7334Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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