Histological survey for oxalate nephrosis in Victorian koalas (Phascolarctos cinereus).
disease
kidney
koala
nephrosis
oxalate
phascolarctidae
Journal
Australian veterinary journal
ISSN: 1751-0813
Titre abrégé: Aust Vet J
Pays: England
ID NLM: 0370616
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
16
12
2019
revised:
28
05
2020
accepted:
29
05
2020
pubmed:
10
7
2020
medline:
10
9
2020
entrez:
10
7
2020
Statut:
ppublish
Résumé
The Mount Lofty Ranges koala (Phascolarctos cinereus) population in South Australia has a high prevalence of the renal disease oxalate nephrosis, for which an underlying genetic cause is suspected. South Australian koalas primarily originate from those in French Island, Victoria; however, oxalate nephrosis has not previously been reported in Victorian koalas. Examination of kidney tissue sections from 63 koalas across Victoria found that nine koalas were affected by oxalate nephrosis (14.3%). These included 2/5 koalas from French Island (40%), 4/14 koalas from the western regions (29%), 2/11 Raymond Island koalas (18%), and 1/13 Cape Otway koalas (8%). There were no cases of oxalate nephrosis identified in the Strzelecki koalas (n = 12). These findings suggest that oxalate nephrosis occurs in koalas from French Island and populations that have received significant influx of koalas from French Island, but not in the Strzelecki region, which has little to no French Island input. This lends support to the theory that an inherited abnormality of oxalate metabolism could underlie the high prevalence of oxalate nephrosis in the Mount Lofty Ranges koala population, and molecular investigations are currently underway to investigate a genetic cause.
Substances chimiques
Oxalates
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-470Subventions
Organisme : H&A Bruce Bequest
Organisme : Hermon Slade Foundation
Organisme : MA Ingram and Youngman Trusts
Organisme : Vizard Foundation
Organisme : Wildlife Health Australia
Informations de copyright
© 2020 Australian Veterinary Association.
Références
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