Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function.
antidepressive agents
electron transport chain complex proteins
fluoxetine
ketamine
metabolomics
mice
mitochondria
stress
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
30
06
2020
received:
27
03
2020
accepted:
03
07
2020
pubmed:
10
7
2020
medline:
1
7
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
Antidepressants have been shown to influence mitochondrial function directly, and suboptimal mitochondrial function (SMF) has been implicated in complex psychiatric disorders. In the current study, we used a mouse model for trait SMF to test the hypothesis that chronic fluoxetine treatment in mice subjected to chronic stress would negatively impact brain bioenergetics, a response that would be more pronounced in mice with trait SMF. In contrast, we hypothesized that chronic ketamine treatment would positively impact mitochondrial function in both WT and mice with SMF. We used an animal model for trait SMF, the Ndufs4
Substances chimiques
Ndufs4 protein, mouse
0
Fluoxetine
01K63SUP8D
Ketamine
690G0D6V8H
Electron Transport Complex I
EC 7.1.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2986-3001Informations de copyright
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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