Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.
LPS
MMP
MMP-9
acute inflammation
bivalent carboxylate inhibitor
chemotaxis
endotoxemia
inflammation
leukocytosis
sepsis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
09
06
2020
revised:
30
06
2020
accepted:
02
07
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
13
4
2021
Statut:
epublish
Résumé
A fundamental part of the immune response to infection or injury is leukocyte migration. Matrix metalloproteinases (MMPs) are a class of secreted or cell-bound endopeptidases, implicated in every step of the process of inflammatory cell migration. Hence, specific inhibition of MMPs is an interesting approach to control inflammation. We evaluated the potential of a bivalent carboxylate inhibitor to selectively inhibit the trimeric proteoform of MMP-9 and compared this with a corresponding monovalent inhibitor. The bivalent inhibitor efficiently inhibited trimeric MMP-9 (IC
Identifiants
pubmed: 32645949
pii: cells9071634
doi: 10.3390/cells9071634
pmc: PMC7408547
pii:
doi:
Substances chimiques
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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